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Gria2
Gene Detail
 Symbol
Name
ID
Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
MGI:95809
Synonyms Glur2, Glur-2, GluR2, GluR-B
Feature Type protein coding gene
Genetic Map
Chromosome 3
35.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:80684936-80802791 bp, - strand
From NCBI annotation of GRCm38

  117856 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:20225  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Gria2
Human
homologs
Human Homolog GRIA2, glutamate receptor, ionotropic, AMPA 2
NCBI Gene ID 2891
neXtProt AC  NX_P42262
Human Synonyms  GluA2, GLUR2, GLURB, GluR-K2, HBGR2
Human Chr (Location)  4q32.1; chr4:158141736-158287227 (+)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(14) : Targeted(14)
 
Homozygotes for targeted null mutations exhibit epilepsy, deficient dendritic architecture, altered exploratory behavior, impaired motor and learning performance, and increased mortality.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (58 annotations)
Process establishment of protein localization, ionotropic glutamate receptor signaling pathway, ...
Component alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex, asymmetric synapse, ...
Function alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity, extracellular-glutamate-gated ion channel activity, ...
External Resources: FuncBase
Expression Literature Summary: (30 records)
Data Summary: Results (153)    Tissues (80)    Images (34)
Theiler Stages: 19, 23, 26, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 101
Western blot 1
RT-PCR 46
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents 		All nucleic(27) Genomic(6) cDNA(20) Primer pair(1)
Microarray probesets(8)
Other database
links
Ensembl Gene ModelENSMUSG00000033981 (Evidence)
Entrez Gene14800 (Evidence)
DFCITC1576518, TC1592523, TC1610088, TC1611503, TC1666157, TC1683106, TC1688019, TC1712669
DoTSDT.101129087, DT.101325440, DT.101710699, DT.55224955, DT.91331351, DT.91575170, DT.99852757
NIA Mouse Gene IndexU024181, U051190
Consensus CDS ProjectCCDS17423.1, CCDS38459.1
International Mouse Knockout Project StatusGria2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14800 NCBI Gene Model | MGI Sequence Detail 117856 C57BL/6J ±  kb
transcript NM_013540 RefSeq | MGI Sequence Detail 6841 C57BL/6 
polypeptide P23819 UniProt | EBI | MGI Sequence Detail 883 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(6) UniProt(9)
Polymorphisms RFLP(1) : SNPs(630 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008234 glutamate receptor 2
Graphical View of Protein Domain Structure
References (Earliest) J:10801 Sakimura K, et al., Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. FEBS Lett. 1990 Oct 15;272(1-2):73-80
(Latest) J:191674 Miyamoto M, et al., Involvement of AMPA receptor GluR2 and GluR3 trafficking in trigeminal spinal subnucleus caudalis and C1/C2 neurons in acute-facial inflammatory pain. PLoS One. 2012;7(8):e44055
All references(153)
Other
accession IDs 		MGD-MRK-10141, MGD-MRK-10148, MGD-MRK-10247
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory