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Gnb1
Gene Detail
 Symbol
Name
ID
Gnb1
guanine nucleotide binding protein (G protein), beta 1
MGI:95781
Feature Type protein coding gene
Genetic Map
Chromosome 4
86.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr4:155491364-155559269 bp, + strand
From VEGA annotation of GRCm38

  67906 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:55532  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: guanine nucleotide-binding protein, beta subunit
Gene Tree: Gnb1
Human
homologs
Human Homolog GNB1, guanine nucleotide binding protein (G protein), beta polypeptide 1
NCBI Gene ID 2782
neXtProt AC  NX_P62873
Human Chr (Location)  1p36.33; chr1:1716725-1822526 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(76) : Targeted(1) Gene trapped(75)
 
The distal break point for the In(4)56Rk inversion is located within this gene. This inversion is associated with the phenotypic marker Rd4. These mice have an abnormal retanl morphology. Homozygous mutant of this gene results in prenatal or perinatal lethality with exencephaly or smaller brain.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (27 annotations)
Process cardiac muscle cell apoptotic process, cell proliferation, ...
Component cell body, dendrite, ...
Function G-protein coupled receptor binding, GTPase activity, ...
External Resources: FuncBase
Expression Literature Summary: (8 records)
Data Summary: Results (63)    Tissues (60)    Images (4)
Theiler Stages: 1, 2, 3, 4, 15, 19, 22, 23, 28
Assay TypeResults
RNA in situ 7
RT-PCR 56
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(19) Genomic(1) cDNA(15) Primer pair(2) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000010708 (Evidence)
Ensembl Gene ModelENSMUSG00000029064 (Evidence)
Entrez Gene14688 (Evidence)
DFCITC1573395, TC1593510, TC1595603, TC1606656, TC1646287
DoTSDT.101707166, DT.110772428, DT.87054719, DT.91283215, DT.91344716, DT.94370519
NIA Mouse Gene IndexU042607
Consensus CDS ProjectCCDS19030.1
International Mouse Knockout Project StatusGnb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010708 VEGA Gene Model | MGI Sequence Detail 67906 C57BL/6J ±  kb
transcript OTTMUST00000099389 VEGA | MGI Sequence Detail 2832 Not Applicable 
polypeptide OTTMUSP00000055798 VEGA | MGI Sequence Detail 340 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(6) UniProt(6)
Polymorphisms RFLP(4) : SNPs(208 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR001632 G-protein, beta subunit
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR016346 Guanine nucleotide-binding protein, beta subunit
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000008095 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
References (Earliest) J:9413 Blatt C, et al., Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human. Proc Natl Acad Sci U S A. 1988 Oct;85(20):7642-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(72)
Other
accession IDs 		MGD-MRK-10195, MGD-MRK-10200, MGI:2140144, MGI:2140659
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/22/2013
MGI 5.13 		The Jackson Laboratory