Rapgef2 MGI Mouse Gene Detail - MGI:2659071 - Rap guanine nucleotide exchange factor (GEF) 2

Rapgef2
Gene Detail

Symbol
Name
ID

Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
MGI:2659071

Synonyms

5830453M24Rik, CNRasGEF, mKIAA0313, nRapGEP, Pdzgef1, RA-GEF-1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

34.91 cM
Detailed Genetic Map ± 1 cM

Mapping data(1)

Sequence Map

Chr3:79062516-79181340 bp, - strand
From VEGA annotation of GRCm38

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:35477 Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rapgef2

Human
homologs

Human Homolog		RAPGEF2, Rap guanine nucleotide exchange factor (GEF) 2
NCBI Gene ID		9693
neXtProt AC		NX_Q9Y4G8
Human Synonyms		CNrasGEF, nRap GEP, NRAPGEP, PDZGEF1, PDZ-GEF1, RA-GEF, Rap-GEP
Human Chr (Location)		4q32.1; chr4:160188998-160281302 (+) GRCh37.p10

Alleles
and
phenotypes

All alleles(10) : Targeted(6) Gene trapped(4)

Homozygotes for a null allele die at mid-gestation exhibiting growth arrest and defects in vascular development, neural tube closure and embryo turning. Homozygotes for another null allele show yolk sac vascular defects, impaired cell physiology and heart, primitive gut, liver and brain formation.

Gene Ontology
(GO)
classifications

All GO classifications: (13 annotations)

Process	positive regulation of Rap GTPase activity, regulation of small GTPase mediated signal transduction, ...
Component	intracellular, membrane, ...
Function	guanyl-nucleotide exchange factor activity, protein kinase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (24) Tissues (9) Images (7)
Theiler Stages: 9, 11, 13, 15, 17, 19, 23

Assay Type	Results
Immunohistochemistry	2
RNA in situ	7
Western blot	9
RT-PCR	6

cDNA source data(7)
External Resources: Allen Institute GEO ArrayExpress

Molecular
reagents

All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000031912 (Evidence)
Ensembl Gene Model	ENSMUSG00000062232 (Evidence)
Entrez Gene	76089 (Evidence)
DFCI	TC1597031, TC1617641
DoTS	DT.101131239, DT.101179992, DT.40142867, DT.91401560
NIA Mouse Gene Index	U024168
Consensus CDS Project	CCDS50932.1
International Mouse Knockout Project Status	Rapgef2

Sequences

All sequences(38) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(418 from dbSNP Build 128)

Protein-related
information

Resource	ID	Description
InterPro	IPR000595	Cyclic nucleotide-binding domain
InterPro	IPR018490	Cyclic nucleotide-binding-like
InterPro	IPR001895	Guanine-nucleotide dissociation stimulator CDC25
InterPro	IPR001478	PDZ domain
InterPro	IPR000159	Ras-association
InterPro	IPR008937	Ras guanine nucleotide exchange factor
InterPro	IPR023578	Ras guanine nucleotide exchange factor, domain
InterPro	IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal
InterPro	IPR014710	RmlC-like jelly roll fold
Protein Ontology	PR:000013727	rap guanine nucleotide exchange factor 2

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:178740 Bilasy SE, et al., RA-GEF-1 (Rapgef2) is essential for proper development of the midline commissures. Neurosci Res. 2011 Nov;71(3):200-9
All references(39)

Other
accession IDs

MGI:1923339

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/05/2013 MGI 5.13