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Slc6a11
Gene Detail
 Symbol
Name
ID
Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
MGI:95630
Synonyms D930045G19Rik, E130202I16Rik, Gabt4, Gat3, GAT4
Feature Type protein coding gene
Genetic Map
Chromosome 6
52.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:114131241-114249886 bp, + strand
From NCBI annotation of GRCm38

  118646 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:129935  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Slc6a11
Human
homologs
Human Homolog SLC6A11, solute carrier family 6 (neurotransmitter transporter, GABA), member 11
NCBI Gene ID 6538
neXtProt AC  NX_P48066
Human Synonyms  GAT3, GAT-3, GAT4
Human Chr (Location)  3p25.3; chr3:10857917-10980146 (+)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(2) : Targeted(2)
 
Mice homozygous for a targeted mutation display postnatal lethality. Mice heterozygous for a targeted mutation display resistance to pharmacologically induced seizures.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (13 annotations)
Process neurotransmitter transport, transport
Component cell projection, cytoplasm, ...
Function gamma-aminobutyric acid:sodium symporter activity, neurotransmitter binding, ...
External Resources: FuncBase
Expression Literature Summary: (7 records)
Data Summary: Results (287)    Tissues (113)    Images (50)
Theiler Stages: 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 146
In situ reporter (knock in) 48
RT-PCR 93
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(26) Genomic(10) cDNA(11) Primer pair(5)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000030307 (Evidence)
Entrez Gene243616 (Evidence)
DFCITC1583554, TC1628169
DoTSDT.55213352, DT.91337373
NIA Mouse Gene IndexU007284
Consensus CDS ProjectCCDS39597.1
International Mouse Knockout Project StatusSlc6a11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 243616 NCBI Gene Model | MGI Sequence Detail 118646 C57BL/6J ±  kb
transcript NM_172890 RefSeq | MGI Sequence Detail 4066 C57BL/6 
polypeptide P31650 UniProt | EBI | MGI Sequence Detail 627 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(592 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR000175 Sodium:neurotransmitter symporter
InterPro IPR002982 Sodium:neurotransmitter symporter, GABA, GAT-3
Protein Ontology PR:000015177 sodium- and chloride-dependent GABA transporter 3
Graphical View of Protein Domain Structure
References (Earliest) J:3704 Liu QR, et al., Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected] [published erratum appers in J Biol Chem 1993 Apr 25;268(12):9156]. J Biol Chem. 1993 Jan 25;268(3):2106-12
(Latest) J:191581 Zhou Y, et al., Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents. J Biol Chem. 2012 Oct 12;287(42):35733-46
All references(39)
Other
accession IDs 		MGD-MRK-9950, MGI:1925977, MGI:2443874
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory