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Fgfr3
Gene Detail
 Symbol
Name
ID
Fgfr3
fibroblast growth factor receptor 3
MGI:95524
Synonyms Fgfr-3, HBGFR, sam3
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.83 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr5:33721724-33737067 bp, + strand
From VEGA annotation of GRCm38

  15344 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:55437  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: fibroblast growth factor receptor
Gene Tree: Fgfr3
Human
homologs
Human Homolog FGFR3, fibroblast growth factor receptor 3
NCBI Gene ID 2261
neXtProt AC  NX_P22607
Human Synonyms  ACH, CD333, CEK2, HSFGFR3EX, JTK4
Human Chr (Location)  4p16.3; chr4:1795039-1810599 (+)  GRCh37.p10
Disease Associations  (13) Diseases Associated with Human FGFR3
Alleles
and
phenotypes 		All alleles(26) : Targeted(25) Spontaneous(1)
 
Mutant alleles generally cause skeletal deformities, with some causing decreased body size, premature death, or hearing loss due to developmental defects of the ear.
 
Human Diseases Modeled Using Mouse Fgfr3 (5)    Alleles Annotated to Human Diseases(9)    Phenotype Images(12)
Gene Ontology
(GO)
classifications 		All GO classifications: (94 annotations)
Process alveolar secondary septum development, apoptotic process, ...
Component cell surface, cytoplasm, ...
Function ATP binding, fibroblast growth factor-activated receptor activity, ...
External Resources: FuncBase
Expression Literature Summary: (148 records)
Data Summary: Results (390)    Tissues (238)    Images (101)
Theiler Stages: 2, 3, 4, 10, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 266
Northern blot 7
RT-PCR 107
RNase protection 8
cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents 		All nucleic(53) Genomic(4) cDNA(28) Primer pair(19) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021524 (Evidence)
Ensembl Gene ModelENSMUSG00000054252 (Evidence)
Entrez Gene14184 (Evidence)
DFCITC1576655, TC1596578
DoTSDT.101351715, DT.101390235, DT.488578, DT.97413536
NIA Mouse Gene IndexU042629
EC2.7.10.1
Consensus CDS ProjectCCDS51464.1, CCDS51465.1, CCDS51466.1, CCDS57335.1
International Mouse Knockout Project StatusFgfr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021524 VEGA Gene Model | MGI Sequence Detail 15344 C57BL/6J ±  kb
transcript OTTMUST00000051048 VEGA | MGI Sequence Detail 4221 Not Applicable 
polypeptide OTTMUSP00000023967 VEGA | MGI Sequence Detail 801 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(10) UniProt(10)
Polymorphisms All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs(45 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016248 Tyrosine-protein kinase, fibroblast growth factor receptor
Protein Ontology PR:000001450 fibroblast growth factor receptor 3
References (Earliest) J:30010 Avivi A, et al., Flg-2, a new member of the family of fibroblast growth factor receptors [published erratum appears in Oncogene 1992 Apr;7(4):823]. Oncogene. 1991 Jun;6(6):1089-92
(Latest) J:196080 Elsen GE, et al., The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4081-6
All references(278)
Other
accession IDs 		MGD-MRK-9778, MGD-MRK-9783
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/05/2013
MGI 5.13 		The Jackson Laboratory