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Dppa4
Gene Detail
 Symbol
Name
ID
Dppa4
developmental pluripotency associated 4
MGI:2157525
Synonyms 2410091M23Rik, ECAT15-1
Feature Type protein coding gene
Genetic Map
Chromosome 16
30.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:48283735-48294292 bp, + strand
From NCBI annotation of GRCm38

  10558 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:130462  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Dppa4
Human
homologs
Human Homolog DPPA4, developmental pluripotency associated 4
NCBI Gene ID 55211
neXtProt AC  NX_Q7L190
Human Synonyms  2410091M23Rik
Human Chr (Location)  3q13.13; chr3:109044988-109056419 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(62) : Targeted(7) Gene trapped(55)
 
Mice homozygous for a knock-out allele exhibit perinatal and postnatal lethality, abnormal lung morphology, skeletal defects, and a maternal effect on female fertility.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (6 annotations)
Process lung-associated mesenchyme development, multicellular organismal development, ...
Component nucleus
External Resources: FuncBase
Expression Literature Summary: (10 records)
Data Summary: Results (81)    Tissues (18)    Images (18)
Theiler Stages: 2, 3, 8, 9, 10, 11, 12, 13, 14, 22, 23, 24
Assay TypeResults
RNA in situ 32
RT-PCR 49
cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(31) cDNA(29) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000058550 (Evidence)
Entrez Gene73693 (Evidence)
UniGene35597
DFCITC1582110, TC1679695
DoTSDT.101196806, DT.530981
Consensus CDS ProjectCCDS28208.1, CCDS28209.1
International Mouse Knockout Project StatusDppa4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 73693 NCBI Gene Model | MGI Sequence Detail 10558 C57BL/6J ±  kb
transcript NM_028610 RefSeq | MGI Sequence Detail 1534 C57BL/6 
polypeptide Q8CCG4 UniProt | EBI | MGI Sequence Detail 296 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(3)
Polymorphisms SNPs(29 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR025891 Developmental pluripotency-associated protein 2/4, C-terminal domain
Protein Ontology PR:000006667 developmental pluripotency-associated protein 4
Graphical View of Protein Domain Structure
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:184928 Miles DC, et al., The proto-oncogene Ret is required for male foetal germ cell survival. Dev Biol. 2012 May 1;365(1):101-9
All references(39)
Other
accession IDs 		MGI:1920943, MGI:2146696
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/22/2013
MGI 5.13 		The Jackson Laboratory