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Tardbp
Gene Detail
 Symbol
Name
ID
Tardbp
TAR DNA binding protein
MGI:2387629
Synonyms 1190002A23Rik, Tdp43, TDP-43
Feature Type protein coding gene
Genetic Map
Chromosome 4
78.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:148612382-148627019 bp, - strand
From VEGA annotation of GRCm38

  14638 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:7221  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tardbp
Human
homologs
Human Homolog TARDBP, TAR DNA binding protein
NCBI Gene ID 23435
neXtProt AC  NX_Q13148
Human Synonyms  ALS10, TDP-43
Human Chr (Location)  1p36.22; chr1:11072679-11085549 (+)  GRCh37.p10
Disease Associations  (1) Diseases Associated with Human TARDBP
Alleles
and
phenotypes 		All alleles(146) : Targeted(7) Gene trapped(139)
 
Homozygous deficient mice display embryonic lethality before somite formation with impaired inner cell mass proliferation.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (14 annotations)
Process 3'-UTR-mediated mRNA stabilization, mRNA processing, ...
Component nucleus
Function DNA binding, double-stranded DNA binding, ...
External Resources: FuncBase
Expression Literature Summary: (9 records)
Data Summary: Results (276)    Tissues (107)    Images (55)
Theiler Stages: 1, 2, 3, 4, 5, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 14
RNA in situ 58
In situ reporter (knock in) 51
Northern blot 4
Western blot 123
RT-PCR 26
cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(40) cDNA(36) Primer pair(4)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000010947 (Evidence)
Ensembl Gene ModelENSMUSG00000041459 (Evidence)
Entrez Gene230908 (Evidence)
NIA Mouse Gene IndexU025792, U069876, U358201
PDB3D2W
Consensus CDS ProjectCCDS38967.1, CCDS38968.1, CCDS38969.1, CCDS38970.1, CCDS38971.1
International Mouse Knockout Project StatusTardbp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010947 VEGA Gene Model | MGI Sequence Detail 14638 C57BL/6J ±  kb
transcript OTTMUST00000025673 VEGA | MGI Sequence Detail 7477 Not Applicable 
polypeptide OTTMUSP00000011770 VEGA | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(11) UniProt(11)
Polymorphisms SNPs(152 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000016057 TAR DNA-binding protein 43
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:193178 Prudencio M, et al., Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21510-5
All references(74)
Other
accession IDs 		MGI:1916123, MGI:2140695
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory