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Erap1
Gene Detail
 Symbol
Name
ID
Erap1
endoplasmic reticulum aminopeptidase 1
MGI:1933403
Synonyms Arts1, ERAAP, PILSAP
Feature Type protein coding gene
Genetic Map
Chromosome 13
40.48 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:74639872-74691875 bp, + strand
From NCBI annotation of GRCm38

  52004 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:56754  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Erap1
Human
homologs
Human Homolog ERAP1, endoplasmic reticulum aminopeptidase 1
NCBI Gene ID 51752
neXtProt AC  NX_Q9NZ08
Human Synonyms  ALAP, A-LAP, APPILS, ARTS1, ARTS-1, ERAAP, ERAAP1, PILSAP, PILS-AP
Human Chr (Location)  5q15; chr5:96096514-96149848 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(10) : Targeted(10)
 
Mice homozygous for a targeted mutation may exhibit extramedullary hematopoiesis of the spleen, thymus hyperplasia, or enlarged kidneys at older ages.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (25 annotations)
Process membrane protein ectodomain proteolysis, metabolic process, ...
Component cytoplasm, endoplasmic reticulum, ...
Function aminopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Results (115)    Tissues (65)    Images (36)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 5
In situ reporter (knock in) 72
RT-PCR 38
cDNA source data(75)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(77) cDNA(76) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021583 (Evidence)
Entrez Gene80898 (Evidence)
UniGene83526
EC3.4.11.-
Consensus CDS ProjectCCDS26647.1
International Mouse Knockout Project StatusErap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 80898 NCBI Gene Model | MGI Sequence Detail 52004 C57BL/6J ±  kb
transcript NM_030711 RefSeq | MGI Sequence Detail 4014 C57BL/6 
polypeptide Q9EQH2 UniProt | EBI | MGI Sequence Detail 930 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(3)
Polymorphisms SNPs(213 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR024571 Domain of unknown function DUF3358
InterPro IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
InterPro IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
Protein Ontology PR:000007155 endoplasmic reticulum aminopeptidase 1
Graphical View of Protein Domain Structure
References (Earliest) J:68745 Miyashita H, et al., A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis. Blood. 2002 May 1;99(9):3241-9
(Latest) J:186455 Nagarajan NA, et al., Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum. Nat Immunol. 2012 Jun;13(6):579-86
All references(42)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/22/2013
MGI 5.13 		The Jackson Laboratory