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Srd5a3
Gene Detail
 Symbol
Name
ID
Srd5a3
steroid 5 alpha-reductase 3
MGI:1930252
Synonyms 1110025P14Rik, D730040M03Rik, Srd5a2l
Feature Type protein coding gene
Genetic Map
Chromosome 5
40.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:76140271-76155504 bp, + strand
From VEGA annotation of GRCm38

  15234 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:41385  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Srd5a3
Human
homologs
Human Homolog SRD5A3, steroid 5 alpha-reductase 3
NCBI Gene ID 79644
neXtProt AC  NX_Q9H8P0
Human Synonyms  CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1
Human Chr (Location)  4q12; chr4:56212388-56239267 (+)  GRCh37.p10
Disease Associations  (2) Diseases Associated with Human SRD5A3
Alleles
and
phenotypes 		All alleles(3) : Targeted(2) Gene trapped(1)
 
Mice homozygous for a gene trapped allele exhibit embryonic lethality between E11.5 and E13.5 with open neural tubes, failure to turn, dilated hearts, and ventral body wall defects.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (17 annotations)
Process dolichol-linked oligosaccharide biosynthetic process, dolichol metabolic process, ...
Component cytoplasm, endoplasmic reticulum, ...
Function 3-oxo-5-alpha-steroid 4-dehydrogenase activity, cholestenone 5-alpha-reductase activity, ...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Results (117)    Tissues (112)   
Theiler Stages: 13, 17, 20, 22, 23, 28
Assay TypeResults
RNA in situ 94
In situ reporter (knock in) 21
RT-PCR 2
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000025182 (Evidence)
Ensembl Gene ModelENSMUSG00000029233 (Evidence)
Entrez Gene57357 (Evidence)
DFCITC1577809, TC1655081, TC1670632, TC1683233
DoTSDT.40161590, DT.87072367, DT.94191820, DT.97408887
NIA Mouse Gene IndexU005698
EC1.3.1.22, 1.3.1.94
Consensus CDS ProjectCCDS19358.1
International Mouse Knockout Project StatusSrd5a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025182 VEGA Gene Model | MGI Sequence Detail 15234 C57BL/6J ±  kb
transcript OTTMUST00000061989 VEGA | MGI Sequence Detail 1747 Not Applicable 
polypeptide OTTMUSP00000030509 VEGA | MGI Sequence Detail 330 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(2) UniProt(4)
Polymorphisms SNPs(124 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR001104 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
Protein Ontology PR:000015610 3-oxo-5-alpha-steroid 4-dehydrogenase 3
References (Earliest) J:66232 Wilsbacher LD, et al., The mouse clock locus: sequence and comparative analysis of 204 Kb from mouse chromosome 5. Genome Res. 2000 Dec;10(12):1928-40
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs 		MGI:1923565, MGI:1925601, MGI:2141123, MGI:2141254
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory