About   Help   FAQ
Chrna2
Gene Detail
 Symbol
Name
ID
Chrna2
cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)
MGI:87886
Synonyms Acra2, Acra-2, MGC:18795
Feature Type protein coding gene
Genetic Map
Chromosome 14
34.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:66140960-66152948 bp, + strand
From VEGA annotation of GRCm38

  11989 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:20193  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Chrna2
Human
homologs
Human Homolog CHRNA2, cholinergic receptor, nicotinic, alpha 2 (neuronal)
NCBI Gene ID 1135
neXtProt AC  NX_Q15822
Human Chr (Location)  8p21; chr8:27317278-27336813 (-)  GRCh37.p10
Disease Associations  (1) Diseases Associated with Human CHRNA2
Alleles
and
phenotypes 		All alleles(2) : Targeted(2)
 
Mice homozygous for a targeted null mutation do not exhibit any significant abnormalities compared to controls.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (25 annotations)
Process ion transport, protein heterooligomerization, ...
Component acetylcholine-gated channel complex, cell junction, ...
Function acetylcholine-activated cation-selective channel activity, acetylcholine binding, ...
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Results (125)    Tissues (58)    Images (19)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 26
In situ reporter (knock in) 36
Northern blot 8
RT-PCR 55
cDNA source data(2)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents 		All nucleic(6) cDNA(4) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000039812 (Evidence)
Ensembl Gene ModelENSMUSG00000022041 (Evidence)
Entrez Gene110902 (Evidence)
UniGene57350
DFCITC1590138
DoTSDT.55116799
NIA Mouse Gene IndexU015784
Consensus CDS ProjectCCDS27219.1
International Mouse Knockout Project StatusChrna2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039812 VEGA Gene Model | MGI Sequence Detail 11989 C57BL/6J ±  kb
transcript OTTMUST00000103500 VEGA | MGI Sequence Detail 3527 Not Applicable 
polypeptide OTTMUSP00000057835 VEGA | MGI Sequence Detail 512 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs(80 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR002394 Nicotinic acetylcholine receptor
Protein Ontology PR:000005455 neuronal acetylcholine receptor subunit alpha-2
References (Earliest) J:10489 Bessis A, et al., Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor. FEBS Lett. 1990 May 7;264(1):48-52
(Latest) J:190149 Bajayo A, et al., Skeletal parasympathetic innervation communicates central IL-1 signals regulating bone mass accrual. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15455-60
All references(39)
Other
accession IDs 		MGD-MRK-1055, MGD-MRK-1059, MGI:2384825
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory