About   Help   FAQ
Pik3cb Gene Detail
Summary
  • Symbol
    Pik3cb
  • Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  • Synonyms
    1110001J02Rik, p110beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922019
    NCBI Gene: 74769
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:98920455-99022264 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 51.41 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    742 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922019
 protein coding gene Chr9:98918707-99022674 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035165
 protein coding gene Chr9:100379512-100497197 (-)
A/J MGP_AJ_G0035146
 protein coding gene Chr9:96842070-96949092 (-)
AKR/J MGP_AKRJ_G0035078
 protein coding gene Chr9:99208872-99317857 (-)
BALB/cJ MGP_BALBcJ_G0035139
 protein coding gene Chr9:96526977-96632035 (-)
C3H/HeJ MGP_C3HHeJ_G0034849
 protein coding gene Chr9:99603587-99714344 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035659
 protein coding gene Chr9:103261256-103383329 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032558
 protein coding gene Chr9:94589586-94695767 (-)
CAST/EiJ MGP_CASTEiJ_G0034160
 protein coding gene Chr9:99410916-99522160 (-)
CBA/J MGP_CBAJ_G0034817
 protein coding gene Chr9:106802688-106920839 (-)
DBA/2J MGP_DBA2J_G0034979
 protein coding gene Chr9:96355879-96461418 (-)
FVB/NJ MGP_FVBNJ_G0034927
 protein coding gene Chr9:95179236-95284796 (-)
LP/J MGP_LPJ_G0035055
 protein coding gene Chr9:100629788-100742409 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034966
 protein coding gene Chr9:108731130-108848752 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035681
 protein coding gene Chr9:99421938-99534322 (-)
PWK/PhJ MGP_PWKPhJ_G0033867
 protein coding gene Chr9:96563201-96676137 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033702
 protein coding gene Chr9:99508858-99624161 (-)
WSB/EiJ MGP_WSBEiJ_G0034280
 protein coding gene Chr9:99322980-99433494 (-)



Homology
more
  • Human Ortholog
    PIK3CB, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3CB, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
  • Synonyms
    P110BETA, PI3K, PI3KBETA, PIK3C1
  • Links
    NCBI Gene ID: 5291
    neXtProt AC: NX_P42338
    UniProt: P42338

  • Chr Location
    3q22.3; chr3:138652698-138834928 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human PIK3CB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 9 alleles in 13 genetic backgrounds
    9 phenotypes from multigenic genotypes
    1 images
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit 30% fetal lethality, decreased size at birth and postnatally, abnormal glucose homeostasis, and dyslipidemia. Mice homozygous for a different knock-out allele die prior to E8.5
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    884
  • Tissues
    130
  • cDNA Data
    44
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74769 NCBI Gene Model | MGI Sequence Detail 101810 C57BL/6J ±  kb
    transcript NM_029094 RefSeq | MGI Sequence Detail 4854 C57BL/6  
    polypeptide Q8BTI9 UniProt | EBI | MGI Sequence Detail 1064 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000012720 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
      (term hierarchy)
    • PDB
      2Y3A, 4BFR
    • EC
      2.7.1.153, 2.7.11.1
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR035892 C2 domain superfamily
      IPR002420 C2 phosphatidylinositol 3-kinase-type domain
      IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
      IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
      IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
      IPR003113 Phosphatidylinositol 3-kinase, adaptor-binding domain
      IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
      IPR015433 Phosphatidylinositol kinase
      IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
      IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
      IPR037702 PI3Kbeta, catalytic domain
      IPR011009 Protein kinase-like domain superfamily
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 44
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143049
    References
    more
    • Summaries
      All 146
      Developmental Gene Expression 13
      Gene Ontology 16
      Phenotypes 68
    • Earliest
      J:214 ALLEN SL, H-2f, a tenth allele at the histocompatibility-2 locus in the mouse as determined by tumor transplantation. Cancer Res. 1955 Jun;15(5):315-9
    • Latest
      J:340018 Bergholz JS, et al., PI3Kbeta controls immune evasion in PTEN-deficient breast tumours. Nature. 2023 May;617(7959):139-146
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory