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Esm1 Gene Detail
Summary
  • Symbol
    Esm1
  • Name
    endothelial cell-specific molecule 1
  • Synonyms
    0610042H23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918940
    NCBI Gene: 71690
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:113346193-113354632 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 63.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918940
 protein coding gene Chr13:113346193-113354638 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020950
 protein coding gene Chr13:115833722-115842135 (+)
A/J MGP_AJ_G0020900
 protein coding gene Chr13:111208081-111216674 (+)
AKR/J MGP_AKRJ_G0020875
 protein coding gene Chr13:114552124-114560537 (+)
BALB/cJ MGP_BALBcJ_G0020900
 protein coding gene Chr13:111891369-111899782 (+)
C3H/HeJ MGP_C3HHeJ_G0020689
 protein coding gene Chr13:114341180-114349593 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021336
 protein coding gene Chr13:119262201-119271291 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018905
 protein coding gene Chr13:106495279-106504206 (+)
CAST/EiJ MGP_CASTEiJ_G0020208
 protein coding gene Chr13:113990521-113998934 (+)
CBA/J MGP_CBAJ_G0020651
 protein coding gene Chr13:123841171-123849584 (+)
DBA/2J MGP_DBA2J_G0020774
 protein coding gene Chr13:110912138-110920551 (+)
FVB/NJ MGP_FVBNJ_G0020758
 protein coding gene Chr13:109604062-109612607 (+)
LP/J MGP_LPJ_G0020850
 protein coding gene Chr13:115878009-115886422 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020786
 protein coding gene Chr13:124129992-124139159 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021372
 protein coding gene Chr13:114032520-114041062 (+)
PWK/PhJ MGP_PWKPhJ_G0019962
 protein coding gene Chr13:109673608-109682262 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019783
 protein coding gene Chr13:110337102-110345430 (+)
WSB/EiJ MGP_WSBEiJ_G0020266
 protein coding gene Chr13:114614563-114622982 (+)



Homology
more
  • Human Ortholog
    ESM1, endothelial cell specific molecule 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ESM1, endothelial cell specific molecule 1
  • Synonyms
    endocan
  • Links
    NCBI Gene ID: 11082
    neXtProt AC: NX_Q9NQ30
    UniProt: Q9NQ30

  • Chr Location
    5q11.2; chr5:54977867-55022671 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show delayed vascular outgrowth and reduced filopodia extension in the retina, reduced leukocyte transmigration, reduced VEGF-induced vascular permeability, and reduced cerebral edema due to ischemic stroke-induced vascular permeability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    36
  • cDNA Data
    11
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042379 Ensembl Gene Model | MGI Sequence Detail 8440 C57BL/6J ±  kb
    transcript ENSMUST00000038144 Ensembl | MGI Sequence Detail 2097 Not Applicable  
    polypeptide ENSMUSP00000040187 Ensembl | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007200 endothelial cell-specific molecule 1
      (term hierarchy)
    • InterPro Domains
      IPR038850 Endothelial cell-specific molecule 1
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR000867 Insulin-like growth factor-binding protein, IGFBP
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 11
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145384
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 11
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:344933 Zheng X, et al., Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice. Kidney360. 2022 Dec 29;3(12):2059-2076
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory