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Pofut2
Gene Detail
 Symbol
Name
ID
Pofut2
protein O-fucosyltransferase 2
MGI:1916863
Synonyms 2310011G23Rik, FUT13, MGC:6943
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:77259300-77269586 bp, + strand
From NCBI annotation of GRCm38

  10287 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12724  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Pofut2

Human
homologs
Human Homolog POFUT2, protein O-fucosyltransferase 2
NCBI Gene ID 23275
neXtProt AC  NX_Q9Y2G5
Human Synonyms  C21orf80, FUT13
Human Chr (Location)  21q22.3; chr21:45263928-45287896 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Genomic Mutations involving Pofut2 (3)
 
Homozygous mutation of this gene results in lethality before weaning.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Pofut2 interacts with 111 markers (Mir15a, Mir17, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process carbohydrate metabolic process, fucose metabolic process, ...
Component endoplasmic reticulum, Golgi apparatus
Function fucosyltransferase activity, peptide-O-fucosyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (254)    Tissues (145)    Images (27)
Theiler Stages: 9, 11, 13, 15, 17, 20, 22, 23, 26, 28
Assay TypeResults
RNA in situ 192
In situ reporter (knock in) 36
RT-PCR 26
cDNA source data(91)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(97) cDNA(93) Primer pair(4)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000020260 (Evidence)
Entrez Gene80294 (Evidence)
UniGene203556
DFCITC1572825
DoTSDT.110624058, DT.533532
NIA Mouse Gene IndexU011684
EC2.4.1.221
Consensus CDS ProjectCCDS23954.1
International Mouse Knockout Project StatusPofut2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 80294 NCBI Gene Model | MGI Sequence Detail 10287 C57BL/6J ±  kb
transcript NM_030262 RefSeq | MGI Sequence Detail 2219 C57BL/6 
polypeptide Q8VHI3 UniProt | EBI | MGI Sequence Detail 429 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(3) UniProt(4)
Polymorphisms SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019378 GDP-fucose protein O-fucosyltransferase
Protein Ontology PR:000012959 GDP-fucose protein O-fucosyltransferase 2
Graphical View of Protein Domain Structure
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:165751 Du J, et al., O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
All references(41)
Other
accession IDs
MGI:1933140, MGI:2143552

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory