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Pdcd2l Gene Detail
Summary
  • Symbol
    Pdcd2l
  • Name
    programmed cell death 2-like
  • Synonyms
    6030457N17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915329
    NCBI Gene: 68079
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:33883924-33896086 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 19.45 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    163 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915329
protein coding gene Chr7:33883922-33896154 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032073
protein coding gene Chr7:33441777-33454381 (-)
A/J MGP_AJ_G0032052
protein coding gene Chr7:32617491-32631001 (-)
AKR/J MGP_AKRJ_G0031986
protein coding gene Chr7:33395065-33407239 (-)
BALB/cJ MGP_BALBcJ_G0032060
protein coding gene Chr7:32901433-32921630 (-)
C3H/HeJ MGP_C3HHeJ_G0031777
protein coding gene Chr7:34280443-34293137 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032537
protein coding gene Chr7:35156027-35170579 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029570
protein coding gene Chr7:33357668-33370433 (-)
CAST/EiJ MGP_CASTEiJ_G0031112
protein coding gene Chr7:25398351-25410005 (-)
CBA/J MGP_CBAJ_G0031745
protein coding gene Chr7:36243573-36259251 (-)
DBA/2J MGP_DBA2J_G0031897
protein coding gene Chr7:32473795-32485232 (-)
FVB/NJ MGP_FVBNJ_G0031852
protein coding gene Chr7:32382432-32395113 (-)
LP/J MGP_LPJ_G0031974
protein coding gene Chr7:33813551-33828426 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031890
protein coding gene Chr7:35298225-35313215 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032552
protein coding gene Chr7:32914512-32928406 (-)
PWK/PhJ MGP_PWKPhJ_G0030834
protein coding gene Chr7:25783616-25796456 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030669
protein coding gene Chr7:22478939-22499051 (-)
WSB/EiJ MGP_WSBEiJ_G0031222
protein coding gene Chr7:33461070-33471720 (-)



Homology
more
  • Human Ortholog
    PDCD2L, programmed cell death 2 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDCD2L, programmed cell death 2 like
  • Links
    NCBI Gene ID: 84306
    neXtProt AC: NX_Q9BRP1
    UniProt: Q9BRP1

  • Chr Location
    19q13.11; chr19:34404399-34426168 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit prenatal lethality, mostly before E12.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002635 Ensembl Gene Model | MGI Sequence Detail 12163 C57BL/6J ±  kb
transcript ENSMUST00000002710 Ensembl | MGI Sequence Detail 1295 Not Applicable  
polypeptide ENSMUSP00000002710 Ensembl | MGI Sequence Detail 364 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    cDNA 53

    Microarray probesets 4
References
more
  • Summaries
    All 28
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:306721 Houston BJ, et al., Programmed Cell Death 2-Like (Pdcd2l) Is Required for Mouse Embryonic Development. G3 (Bethesda). 2020 Dec 3;10(12):4449-4457

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory