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Rgs10
Gene Detail
Symbol

Name
ID
Rgs10
regulator of G-protein signalling 10
MGI:1915115
Synonyms
2310010N19Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 7
70.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:128373621-128418758 bp, - strand
From VEGA annotation of GRCm38

  45138 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37710  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: RGS10
Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs10

Human
homologs
RGS10, regulator of G-protein signaling 10
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6001
neXtProt AC: NX_O43665

Human Chr (Location): 10q25; chr10:119499827-119542710 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(8) Targeted(1)
 
A gene trap mutation of this gene results in impaired glucose tolerance and increased fasting glucose levels whereas a targeted knockout shows defects in osteoclast differentiation and in the skeleton.
 
Interactions
Rgs10 interacts with 51 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process negative regulation of signal transduction, positive regulation of GTPase activity, ...
Component axon terminus, cytoplasm, ...
Function GTPase activator activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (10)    Tissues (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 10
cDNA source data(39)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rgs10    NEW 
Molecular
reagents
All nucleic(40) cDNA(39) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022902 (Evidence)
Ensembl Gene Model ENSMUSG00000030844 (Evidence)
Entrez Gene 67865 (Evidence)
UniGene 18635
DFCI TC1578141
DoTS DT.531098, DT.94256530
NIA Mouse Gene Index U029321
Consensus CDS Project CCDS21896.1
International Mouse Phenotyping Consortium Status Rgs10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022902 VEGA Gene Model | MGI Sequence Detail 45138 C57BL/6J ±  kb
transcript OTTMUST00000055088 VEGA | MGI Sequence Detail 880 Not Applicable 
polypeptide OTTMUSP00000026329 VEGA | MGI Sequence Detail 181 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(270 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016137 RGS domain
InterPro IPR024066 RGS, subdomain 1
Protein Ontology PR:000013945 regulator of G-protein signaling 10
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:222283 Kannarkat GT, et al., Age-related changes in regulator of G-protein signaling (RGS)-10 expression in peripheral and central immune cells may influence the risk for age-related degeneration. Neurobiol Aging. 2015 May;36(5):1982-93
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory