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Uchl5 Gene Detail
Summary
  • Symbol
    Uchl5
  • Name
    ubiquitin carboxyl-terminal esterase L5
  • Synonyms
    5830413B11Rik, Uch37
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914848
    NCBI Gene: 56207
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:143653010-143683204 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 62.54 cM, cytoband F
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914848
 protein coding gene Chr1:143652993-143683204 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016564
 protein coding gene Chr1:148134733-148167268 (+)
A/J MGP_AJ_G0016547
 protein coding gene Chr1:142226882-142260960 (+)
AKR/J MGP_AKRJ_G0016512
 protein coding gene Chr1:146593420-146625193 (+)
BALB/cJ MGP_BALBcJ_G0016507
 protein coding gene Chr1:142650467-142683043 (+)
C3H/HeJ MGP_C3HHeJ_G0016332
 protein coding gene Chr1:146708660-146739480 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016968
 protein coding gene Chr1:153125937-153161565 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014677
 protein coding gene Chr1:135038278-135069029 (+)
CAST/EiJ MGP_CASTEiJ_G0015911
 protein coding gene Chr1:146130563-146163243 (+)
CBA/J MGP_CBAJ_G0016306
 protein coding gene Chr1:158570705-158613287 (+)
DBA/2J MGP_DBA2J_G0016412
 protein coding gene Chr1:141323705-141360926 (+)
FVB/NJ MGP_FVBNJ_G0016410
 protein coding gene Chr1:139814223-139847357 (+)
LP/J MGP_LPJ_G0016483
 protein coding gene Chr1:149148814-149182520 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016436
 protein coding gene Chr1:164997825-165046296 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017004
 protein coding gene Chr1:146319711-146354335 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0015484
 protein coding gene Chr1:145120057-145156451 (+)
WSB/EiJ MGP_WSBEiJ_G0015974
 protein coding gene Chr1:146356598-146389319 (+)



Homology
more
  • Human Ortholog
    UCHL5, ubiquitin C-terminal hydrolase L5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UCHL5, ubiquitin C-terminal hydrolase L5
  • Synonyms
    CGI-70, INO80R, UCH37, UCH-L5
  • Links
    NCBI Gene ID: 51377
    neXtProt AC: NX_Q9Y5K5
    UniProt: Q9Y5K5

  • Chr Location
    1q31.2; chr1:193012250-193060080 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit embryonic lethality associated with abnormal brain development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    884
  • Tissues
    27
  • cDNA Data
    64
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018189 Ensembl Gene Model | MGI Sequence Detail 30195 C57BL/6J ±  kb
    transcript ENSMUST00000189936 Ensembl | MGI Sequence Detail 1696 Not Applicable  
    polypeptide ENSMUSP00000140106 Ensembl | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 64

      Microarray probesets 7
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:242651 Kim SK, et al., Strain survey and genetic analysis of vasoreactivity in mouse aorta. Physiol Genomics. 2016 Oct 07;:physiolgenomics.00054.2016
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory