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Cntnap2
Gene Detail
 Symbol
Name
ID
Cntnap2
contactin associated protein-like 2
MGI:1914047
Synonyms 5430425M22Rik, Caspr2, mKIAA0868
Feature Type protein coding gene
Genetic Map
Chromosome 6
21.81 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:45060061-47301369 bp, + strand
From VEGA annotation of GRCm38

  2241309 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:69159  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: paranodin
Gene Tree: Cntnap2
Human
homologs
Human Homolog CNTNAP2, contactin associated protein-like 2
NCBI Gene ID 26047
neXtProt AC  NX_Q9UHC6
Human Synonyms  AUTS15, CASPR2, CDFE, NRXN4, PTHSL1
Human Chr (Location)  7q35; chr7:145813453-148118090 (+)  GRCh37.p10
Disease Associations  (2) Diseases Associated with Human CNTNAP2
Alleles
and
phenotypes 		All alleles(16) : Targeted(1) Gene trapped(15)
 
Inactivation of this gene results in molecular abnormalities within the central nervous system, but homozygous mutant mice show no overt phenotype.
 
Human Diseases Modeled Using Mouse Cntnap2 (2)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications 		All GO classifications: (19 annotations)
Process behavior, cell adhesion, ...
Component axolemma, cell surface, ...
Function enzyme binding, protein binding
External Resources: FuncBase
Expression Literature Summary: (6 records)
Data Summary: Results (96)    Tissues (8)    Images (24)
Theiler Stages: 23
Assay TypeResults
RNA in situ 96
cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(5) cDNA(5)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022414 (Evidence)
Ensembl Gene ModelENSMUSG00000039419 (Evidence)
Entrez Gene66797 (Evidence)
DFCITC1583877, TC1597355, TC1625186, TC1645766, TC1669120, TC1682375
DoTSDT.101294345, DT.110485961, DT.55282261, DT.94148155, DT.97359044
NIA Mouse Gene IndexU048250
Consensus CDS ProjectCCDS20094.1, CCDS39475.1
International Mouse Knockout Project StatusCntnap2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022414 VEGA Gene Model | MGI Sequence Detail 2241309 C57BL/6J ±  kb
transcript OTTMUST00000053586 VEGA | MGI Sequence Detail 6983 Not Applicable 
polypeptide OTTMUSP00000025482 VEGA | MGI Sequence Detail 1332 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(4) UniProt(4)
Polymorphisms SNPs(10895 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR000421 Coagulation factor 5/8 C-terminal type domain
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR001791 Laminin G domain
InterPro IPR003585 Neurexin/syndecan/glycophorin C
Protein Ontology PR:000005673 contactin-associated protein-like 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190692 Anderson GR, et al., Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18120-5
All references(49)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory