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Cntnap2
Gene Detail
 Symbol
Name
ID
Cntnap2
contactin associated protein-like 2
MGI:1914047
Synonyms 5430425M22Rik, Caspr2, mKIAA0868
Feature Type protein coding gene
Genetic Map
Chromosome 6
21.81 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:45060061-47301369 bp, + strand
From VEGA annotation of GRCm38

  2241309 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69159  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: paranodin
Gene Tree: Cntnap2

Human
homologs
Human Homolog CNTNAP2, contactin associated protein-like 2
NCBI Gene ID 26047
neXtProt AC  NX_Q9UHC6
Human Synonyms  AUTS15, CASPR2, CDFE, NRXN4, PTHSL1
Human Chr (Location)  7q35; chr7:146116361-148420998 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human CNTNAP2
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(15) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this gene results in molecular abnormalities within the central nervous system, but homozygous mutant mice show no overt phenotype.
 
Human Diseases Modeled Using Mouse Cntnap2 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Cntnap2 interacts with 351 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process adult behavior, cell adhesion, ...
Component axolemma, cell surface, ...
Function enzyme binding, protease binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (96)    Tissues (8)    Images (24)
Theiler Stages: 23
Assay TypeResults
RNA in situ 96
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022414 (Evidence)
Ensembl Gene ModelENSMUSG00000039419 (Evidence)
Entrez Gene66797 (Evidence)
DFCITC1583877, TC1597355, TC1625186, TC1645766, TC1669120, TC1682375
DoTSDT.101294345, DT.110485961, DT.55282261, DT.94148155, DT.97359044
NIA Mouse Gene IndexU048250
Consensus CDS ProjectCCDS20094.1, CCDS39475.1
International Mouse Knockout Project StatusCntnap2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022414 VEGA Gene Model | MGI Sequence Detail 2241309 C57BL/6J ±  kb
transcript OTTMUST00000053586 VEGA | MGI Sequence Detail 6983 Not Applicable 
polypeptide OTTMUSP00000025482 VEGA | MGI Sequence Detail 1332 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(13721 from dbSNP Build 137)    SNPs within 2kb including multiple locations(13905)
Protein-related
information
ResourceIDDescription
InterPro IPR000421 Coagulation factor 5/8 C-terminal type domain
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR001791 Laminin G domain
InterPro IPR003585 Neurexin/syndecan/glycophorin C
Protein Ontology PR:000005673 contactin-associated protein-like 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(51)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory