About   Help   FAQ
Psenen
Gene Detail
 Symbol
Name
ID
Psenen
presenilin enhancer 2 homolog (C. elegans)
MGI:1913590
Synonyms 1700023M09Rik
Feature Type protein coding gene
Genetic Map
Chromosome 7
18.60 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:30561868-30563184 bp, - strand
From Ensembl annotation of GRCm38

  1317 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11952  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Psenen

Human
homologs
Human Homolog PSENEN, presenilin enhancer gamma secretase subunit
NCBI Gene ID 55851
neXtProt AC  NX_Q9NZ42
Human Synonyms  MSTP064, PEN2, PEN-2
Human Chr (Location)  19q13.12; chr19:35745577-35747155 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PSENEN
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Homozygous mutation of this gene results in lethality before weaning.
 
Interactions
Psenen interacts with 24 markers (Mir30c-1, Mir30c-2, Mir137, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process membrane protein ectodomain proteolysis, Notch receptor processing, ...
Component endoplasmic reticulum, Golgi apparatus, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 24
cDNA source data(111)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(111) cDNA(111)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000036835 (Evidence)
Entrez Gene66340 (Evidence)
UniGene86557
DFCITC1576472
NIA Mouse Gene IndexU028389, U054628, U056137
Consensus CDS ProjectCCDS21099.1
International Mouse Knockout Project StatusPsenen
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036835 Ensembl Gene Model | MGI Sequence Detail 1317 C57BL/6J ±  kb
transcript ENSMUST00000043898 Ensembl | MGI Sequence Detail 648 Not Applicable 
polypeptide ENSMUSP00000044682 Ensembl | MGI Sequence Detail 101 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019379 Gamma-secretase aspartyl protease complex, presenilin enhancer-2 subunit
Protein Ontology PR:000013346 gamma-secretase subunit PEN-2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory