About   Help   FAQ
Gucy1a3
Gene Detail
 Symbol
Name
ID
Gucy1a3
guanylate cyclase 1, soluble, alpha 3
MGI:1926562
Synonyms 1200016O07Rik, alpha 1 sGC
Feature Type protein coding gene
Genetic Map
Chromosome 3
35.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:82092428-82145877 bp, - strand
From Ensembl annotation of GRCm38

  53450 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:37360  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: soluble guanylate cyclase
Gene Tree: Gucy1a3
Human
homologs
Human Homolog GUCY1A3, guanylate cyclase 1, soluble, alpha 3
NCBI Gene ID 2982
neXtProt AC  NX_Q02108
Human Synonyms  GC-SA3, GUC1A3, GUCA3, GUCSA3, GUCY1A1
Human Chr (Location)  4q31.1-q31.2; chr4:156587862-156658214 (+)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(4) : Targeted(4)
 
Mice homozygous for a null mutation display mild elevation of systolic blood pressure, and abnormal blood vessel and platelet responses to NO.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (20 annotations)
Process cGMP biosynthetic process, cyclic nucleotide biosynthetic process, ...
Component cytoplasm, guanylate cyclase complex, soluble, ...
Function GTP binding, guanylate cyclase activity, ...
External Resources: FuncBase
Expression Literature Summary: (7 records)
Data Summary: Results (465)    Tissues (157)    Images (60)
Theiler Stages: 20, 21, 22, 23
Assay TypeResults
RNA in situ 463
RT-PCR 2
cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents 		All nucleic(14) Genomic(1) cDNA(11) Primer pair(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000033910 (Evidence)
Entrez Gene60596 (Evidence)
DFCITC1576525
DoTSDT.101349795, DT.60104324
NIA Mouse Gene IndexU024189
EC4.6.1.2
Consensus CDS ProjectCCDS17429.1
International Mouse Knockout Project StatusGucy1a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033910 Ensembl Gene Model | MGI Sequence Detail 53450 C57BL/6J ±  kb
transcript ENSMUST00000048976 Ensembl | MGI Sequence Detail 4653 Not Applicable 
polypeptide ENSMUSP00000048918 Ensembl | MGI Sequence Detail 691 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms SNPs(328 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro IPR011645 Haem NO binding associated
InterPro IPR011644 Heme-NO binding
Protein Ontology PR:000008349 guanylate cyclase soluble subunit alpha-3
References (Earliest) J:64709 Sharina IG, et al., Genomic organization of alpha 1 and beta 1 subunits of the mammalian soluble guanylyl cyclase genes. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10878-83
(Latest) J:188294 Buys ES, et al., Genetic modifiers of hypertension in soluble guanylate cyclase alpha1-deficient mice. J Clin Invest. 2012 Jun 1;122(6):2316-25
All references(51)
Other
accession IDs 		MGI:1921380
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
06/05/2013
MGI 5.13 		The Jackson Laboratory