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Gabrq Gene Detail
Summary
  • Symbol
    Gabrq
  • Name
    gamma-aminobutyric acid (GABA) A receptor, subunit theta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888498
    NCBI Gene: 57249
  • Gene Overview
    MyGene.info: GABRQ
Location & Maps
more
  • Sequence Map
    ChrX:72825178-72842602 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17425 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GABRQ, gamma-aminobutyric acid type A receptor theta subunit
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GABRQ, gamma-aminobutyric acid type A receptor theta subunit
    Orthology source: HomoloGene
  • Synonyms
    THETA
  • Links
    NCBI Gene ID: 55879
    neXtProt AC: NX_Q9UN88

  • Chr Location
    Xq28; chrX:152637895-152659510 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Targeted
    2
  • Incidental Mutations
    APF
Males hemizygous for a mutation in this gene exhibit decreased prepulse inhibition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017852 VEGA Gene Model | MGI Sequence Detail 17425 C57BL/6J ±  kb
transcript OTTMUST00000043205 VEGA | MGI Sequence Detail 2000 Not Applicable  
polypeptide OTTMUSP00000019435 VEGA | MGI Sequence Detail 638 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    67 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007781 gamma-aminobutyric acid receptor subunit theta
  • InterPro Domains
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR008101 Gamma-aminobutyric-acid A receptor theta subunit
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Molecular
Reagents
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  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 23
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:62100 Sinkkonen ST, et al., GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus. J Neurosci. 2000 May 15;20(10):3588-95
  • Latest
    J:221789 Mo J, et al., Early growth response 1 (Egr-1) directly regulates GABAA receptor alpha2, alpha4, and theta subunits in the hippocampus. J Neurochem. 2015 May;133(4):489-500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory