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Trpm5
Gene Detail
Symbol

Name
ID
Trpm5
transient receptor potential cation channel, subfamily M, member 5
MGI:1861718
Synonyms
9430099A16Rik, Ltrpc5, Mtr1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
88.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr7:143069153-143094642 bp, - strand
From VEGA annotation of GRCm38

  25490 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22818  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: TRPM5
Protein SuperFamily: transient receptor potential cation channels TRPM4/TRPM5
Gene Tree: Trpm5

Human
homologs
TRPM5, transient receptor potential cation channel, subfamily M, member 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 29850
neXtProt AC: NX_Q9NZQ8

Human Synonyms: LTRPC5, MTR1

Human Chr (Location): 11p15.5; chr11:2403952-2435017 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice demonstrate abnormal taste perception, responding to sour and salty stimuli but not to sweet, or bitter stimuli.
 
Interactions
Trpm5 interacts with 115 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cation transport, ion transmembrane transport, ...
Component dendrite, integral component of membrane, ...
Function calcium activated cation channel activity, potassium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (222)    Tissues (138)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 73
In situ reporter (knock in) 35
RT-PCR 114
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase trpm4 ; ZFIN trpm5    NEW 
Molecular
reagents
All nucleic(25) Genomic(2) cDNA(16) Primer pair(7)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022683 (Evidence)
Ensembl Gene Model ENSMUSG00000009246 (Evidence)
Entrez Gene 56843 (Evidence)
UniGene 286668
DFCI TC1616422, TC1683575, TC1585762
DoTS DT.94236103, DT.91394818, DT.91387732, DT.87048507, DT.101722863, DT.101352813
NIA Mouse Gene Index U029493
Consensus CDS Project CCDS52462.1
International Mouse Phenotyping Consortium Status Trpm5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022683 VEGA Gene Model | MGI Sequence Detail 25490 C57BL/6J ±  kb
transcript OTTMUST00000054375 VEGA | MGI Sequence Detail 4123 Not Applicable 
polypeptide OTTMUSP00000025953 VEGA | MGI Sequence Detail 1158 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(6) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(141 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000016701 transient receptor potential cation channel subfamily M member 5
References
(Earliest) J:63552 Yatsuki H, et al., Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human. DNA Res. 2000 Jun 30;7(3):195-206
(Latest) J:217303 Koudelka J, et al., Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system. Neural Dev. 2014;9:21
All references(78)
Other
accession IDs
MGI:2443185

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory