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Avpr1a
Gene Detail
 Symbol
Name
ID
Avpr1a
arginine vasopressin receptor 1A
MGI:1859216
Synonyms V1aR
Feature Type protein coding gene
Genetic Map
Chromosome 10
70.36 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:122448499-122453453 bp, + strand
From VEGA annotation of GRCm38

  4955 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:568  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: vasopressin/oxytocin receptor
Gene Tree: Avpr1a
Human
homologs
Human Homolog AVPR1A, arginine vasopressin receptor 1A
NCBI Gene ID 552
neXtProt AC  NX_P37288
Human Synonyms  AVPR1, AVPR V1a, V1aR
Human Chr (Location)  12q14-q15; chr12:63536539-63546590 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(4) : Targeted(4)
 
Mice homozygous for disruptions in this gene display a stimulus processing deficit similar to that seen in schizophrenia. Anxiety-like behaviors are reduced in males but not females. B cell development is also affected.
 
Human Diseases Modeled Using Mouse Avpr1a (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications 		All GO classifications: (38 annotations)
Process calcium-mediated signaling, elevation of cytosolic calcium ion concentration, ...
Component cytoplasmic vesicle, integral to membrane, ...
Function G-protein coupled receptor activity, peptide hormone binding, ...
External Resources: FuncBase
Expression Literature Summary: (7 records)
Data Summary: Results (146)    Tissues (76)    Images (27)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 56
In situ reporter (knock in) 52
RT-PCR 38
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents 		All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000020920 (Evidence)
Ensembl Gene ModelENSMUSG00000020123 (Evidence)
Entrez Gene54140 (Evidence)
UniGene4351
DFCITC1583605
DoTSDT.487709
NIA Mouse Gene IndexU086756
Consensus CDS ProjectCCDS24215.1
International Mouse Knockout Project StatusAvpr1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020920 VEGA Gene Model | MGI Sequence Detail 4955 C57BL/6J ±  kb
transcript OTTMUST00000049450 VEGA | MGI Sequence Detail 2671 Not Applicable 
polypeptide OTTMUSP00000022915 VEGA | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms SNPs(53 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR015076 Domain of unknown function DUF1856
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001817 Vasopressin receptor
InterPro IPR001224 Vasopressin V1A receptor
Protein Ontology PR:000001681 vasopressin V1a receptor
References (Earliest) J:75961 Wesley VJ, et al., Agonist-specific, high-affinity binding epitopes are contributed by an arginine in the N-terminus of the human oxytocin receptor. Biochemistry. 2002 Apr 23;41(16):5086-92
(Latest) J:192500 Hammock EA, et al., Modulation of parvalbumin interneuron number by developmentally transient neocortical vasopressin receptor 1a (V1aR). Neuroscience. 2012 Oct 11;222:20-8
All references(58)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/05/2013
MGI 5.13 		The Jackson Laboratory