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Pkd2l2
Gene Detail
 Symbol
Name
ID
Pkd2l2
polycystic kidney disease 2-like 2
MGI:1858231
Synonyms Polycystin - L2, TRPP5
Feature Type protein coding gene
Genetic Map
Chromosome 18
18.62 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:34409423-34442789 bp, + strand
From NCBI annotation of GRCm38

  33367 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:22812  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: transient receptor potential cation channel, subfamily P
Gene Tree: Pkd2l2
Human
homologs
Human Homolog PKD2L2, polycystic kidney disease 2-like 2
NCBI Gene ID 27039
neXtProt AC  NX_Q9NZM6
Human Synonyms  TRPP5
Human Chr (Location)  5q31; chr5:137225125-137276156 (+)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(5) : Targeted(4) Gene trapped(1)
 
Mice homozygous for a targeted gene disruption display hyperactivity.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (9 annotations)
Process detection of mechanical stimulus, ion transmembrane transport, ...
Component integral to membrane, membrane
Function calcium channel activity, calcium ion binding, ...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Results (106)    Tissues (54)    Images (6)
Theiler Stages: 25, 26, 28
Assay TypeResults
In situ reporter (knock in) 50
RT-PCR 56
cDNA source data(55)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(61) Genomic(1) cDNA(56) Primer pair(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000014503 (Evidence)
Entrez Gene53871 (Evidence)
UniGene445792
DFCITC1586251
DoTSDT.110758936, DT.55116473, DT.87060033, DT.94158039, DT.97390128, DT.97412184
NIA Mouse Gene IndexU018540
Consensus CDS ProjectCCDS29127.1
International Mouse Knockout Project StatusPkd2l2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 53871 NCBI Gene Model | MGI Sequence Detail 33367 C57BL/6J ±  kb
transcript NM_016927 RefSeq | MGI Sequence Detail 2461 C57BL/6 
polypeptide Q9JLG4 UniProt | EBI | MGI Sequence Detail 621 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(4)
Polymorphisms SNPs(192 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR003915 Polycystic kidney disease type 2 protein
InterPro IPR013122 Polycystin cation channel, PKD1/PKD2
Protein Ontology PR:000012775 polycystic kidney disease 2-like 2 protein
Graphical View of Protein Domain Structure
References (Earliest) J:61533 Guo L, et al., Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization. Genomics. 2000 Mar 15;64(3):241-51
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory