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Chst3 Gene Detail
Summary
  • Symbol
    Chst3
  • Name
    carbohydrate (chondroitin 6/keratan) sulfotransferase 3
  • Synonyms
    C6ST, C6ST-1, GST-0
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858224
    NCBI Gene: 53374
Location & Maps
more
  • Sequence Map
    Chr10:60181534-60194239 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12706 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CHST3, carbohydrate sulfotransferase 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CHST3, carbohydrate sulfotransferase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C6ST, C6ST1, HSD
  • Links
    NCBI Gene ID: 9469
    neXtProt AC: NX_Q7LGC8

  • Chr Location
    10q22.1; chr10:71964362-72013564 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Chst3 mouse models; 2 with human CHST3 associations

Human Disease Mouse Models
       Schizophrenia; SCZD   OMIM: 181500 View 1 model
       Multiple Joint Dislocations, Short Stature, and Craniofacial Dysmorphism with or without Congenital Heart Defects; JDSCD   OMIM: 245600
Spondyloepiphyseal Dysplasia with Congenital Joint Dislocations; SEDCJD   OMIM: 143095
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Chst3
  • Incidental Mutations
Homozygous mutation of this gene results in significantly reduced numbers of naive T lymphocytes in the spleen at 5-6 weeks of age. Brain development and morphology is normal in mutant animals but for some alleles behavioral abnormalities are seen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035235 VEGA Gene Model | MGI Sequence Detail 12706 C57BL/6J ±  kb
transcript OTTMUST00000089819 VEGA | MGI Sequence Detail 5985 Not Applicable  
polypeptide OTTMUSP00000049122 VEGA | MGI Sequence Detail 472 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    350 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 18
    Primer pair 3

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:47830 Uchimura K, et al., Mouse chondroitin 6-sulfotransferase: molecular cloning, characterization and chromosomal mapping. Glycobiology. 1998 May;8(5):489-96
  • Latest
    J:229564 Yutsudo N, et al., Involvement of chondroitin 6-sulfation in temporal lobe epilepsy. Exp Neurol. 2015 Dec;274(Pt B):126-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory