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Chst3
Gene Detail
 Symbol
Name
ID
Chst3
carbohydrate (chondroitin 6/keratan) sulfotransferase 3
MGI:1858224
Synonyms C6ST, C6ST-1, GST-0
Feature Type protein coding gene
Genetic Map
Chromosome 10
29.70 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:60181534-60194239 bp, - strand
From VEGA annotation of GRCm38

  12706 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:3156  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: carbohydrate sulfotransferase
Gene Tree: Chst3
Human
homologs
Human Homolog CHST3, carbohydrate (chondroitin 6) sulfotransferase 3
NCBI Gene ID 9469
neXtProt AC  NX_Q7LGC8
Human Synonyms  C6ST, C6ST1, HSD
Human Chr (Location)  10q22.1; chr10:73724120-73773322 (+)  GRCh37.p10
Disease Associations  (2) Diseases Associated with Human CHST3
Alleles
and
phenotypes 		All alleles(10) : Targeted(4) Gene trapped(6)
 
Homozygous mutation of this gene results in significantly reduced numbers of naive T lymphocytes in the spleen at 5-6 weeks of age. Brain development and morphology is normal in mutant animals but for some alleles behavioral abnormalities are seen.
 
Human Diseases Modeled Using Mouse Chst3 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications 		All GO classifications: (18 annotations)
Process carbohydrate metabolic process, chondroitin sulfate biosynthetic process, ...
Component Golgi apparatus, Golgi membrane, ...
Function chondroitin 6-sulfotransferase activity, proteoglycan sulfotransferase activity, ...
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Results (234)    Tissues (179)    Images (65)
Theiler Stages: 21, 22, 28
Assay TypeResults
RNA in situ 98
In situ reporter (knock in) 96
RT-PCR 40
cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(21) cDNA(18) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035235 (Evidence)
Ensembl Gene ModelENSMUSG00000057337 (Evidence)
Entrez Gene53374 (Evidence)
UniGene12866
DFCITC1598793, TC1602116, TC1644862, TC1704984
DoTSDT.101198690, DT.488506, DT.87048237
NIA Mouse Gene IndexU031827
EC2.8.2.17
Consensus CDS ProjectCCDS23871.2
International Mouse Knockout Project StatusChst3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035235 VEGA Gene Model | MGI Sequence Detail 12706 C57BL/6J ±  kb
transcript OTTMUST00000089819 VEGA | MGI Sequence Detail 5985 Not Applicable 
polypeptide OTTMUSP00000049122 VEGA | MGI Sequence Detail 472 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(3)
Polymorphisms SNPs(62 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR016469 Carbohydrate sulfotransferase
InterPro IPR000863 Sulfotransferase domain
Protein Ontology PR:000005476 carbohydrate sulfotransferase 3
References (Earliest) J:47830 Uchimura K, et al., Mouse chondroitin 6-sulfotransferase: molecular cloning, characterization and chromosomal mapping. Glycobiology. 1998 May;8(5):489-96
(Latest) J:182313 Miyata S, et al., Persistent cortical plasticity by upregulation of chondroitin 6-sulfation. Nat Neurosci. 2012;15(3):414-22, S1-2
All references(35)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/22/2013
MGI 5.13 		The Jackson Laboratory