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Rab25 Gene Detail
Summary
  • Symbol
    Rab25
  • Name
    RAB25, member RAS oncogene family
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858203
    NCBI Gene: 53868
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:88449335-88455586 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.87 cM, cytoband E3-F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858203
 protein coding gene Chr3:88449335-88455607 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027400
 protein coding gene Chr3:88710332-88717707 (-)
A/J MGP_AJ_G0027364
 protein coding gene Chr3:85716221-85723769 (-)
AKR/J MGP_AKRJ_G0027328
 protein coding gene Chr3:87831836-87838094 (-)
BALB/cJ MGP_BALBcJ_G0027373
 protein coding gene Chr3:85803108-85809388 (-)
C3H/HeJ MGP_C3HHeJ_G0027115
 protein coding gene Chr3:88088792-88095271 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027819
 protein coding gene Chr3:92010499-92017872 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025171
 protein coding gene Chr3:81317611-81323796 (-)
CAST/EiJ MGP_CASTEiJ_G0026561
 protein coding gene Chr3:88331989-88338615 (-)
CBA/J MGP_CBAJ_G0027089
 protein coding gene Chr3:95181376-95187660 (-)
DBA/2J MGP_DBA2J_G0027227
 protein coding gene Chr3:85201680-85207923 (-)
FVB/NJ MGP_FVBNJ_G0027195
 protein coding gene Chr3:83470419-83477544 (-)
LP/J MGP_LPJ_G0027336
 protein coding gene Chr3:89720467-89727745 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027215
 protein coding gene Chr3:101387939-101395747 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027878
 protein coding gene Chr3:87578876-87585160 (-)
PWK/PhJ MGP_PWKPhJ_G0026295
 protein coding gene Chr3:84979960-84986297 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026114
 protein coding gene Chr3:86764395-86770633 (-)
WSB/EiJ MGP_WSBEiJ_G0026643
 protein coding gene Chr3:87933463-87939722 (-)



Homology
more
  • Human Ortholog
    RAB25, RAB25, member RAS oncogene family
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB25, RAB25, member RAS oncogene family
  • Synonyms
    CATX-8, RAB11C
  • Links
    NCBI Gene ID: 57111
    neXtProt AC: NX_P57735
    UniProt: P57735

  • Chr Location
    1q22; chr1:156061160-156070504 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    3 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
On a 129 background, virgin female homozygotes older than 10 months of age develop vaginal cancer while both male and female homozygotes develop distal esophageal stricture due to squamous cell hyperplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    14
  • cDNA Data
    54
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53868 NCBI Gene Model | MGI Sequence Detail 6252 C57BL/6J ±  kb
    transcript NM_016899 RefSeq | MGI Sequence Detail 1060 C57BL/6  
    polypeptide Q9WTL2 UniProt | EBI | MGI Sequence Detail 213 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 1
      cDNA 54

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139927
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:61077 Bhartur SG, et al., Genomic structure of murine Rab11 family members. Biochem Biophys Res Commun. 2000 Mar 16;269(2):611-7
    • Latest
      J:346069 Zhang Z, et al., Rab25 is involved in hypospadias via the beta1 integrin/EGFR pathway. Exp Cell Res. 2024 Feb 23;436(2):113980
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory