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Slamf6 Gene Detail
Summary
  • Symbol
    Slamf6
  • Name
    SLAM family member 6
  • Synonyms
    KAL1, KAL1b, Ly108, NTB-A, SF2000
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353620
    NCBI Gene: 30925
  • Gene Overview
    MyGene.info: SLAMF6
Location & Maps
more
  • Sequence Map
    Chr1:171917515-171953170 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35656 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLAMF6, SLAM family member 6
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLAMF6, SLAM family member 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD352, KALI, KALIb, Ly108, NTBA, NTB-A, SF2000
  • Links
    NCBI Gene ID: 114836
    neXtProt AC: NX_Q96DU3

  • Chr Location
    1q23.2; chr1:160485030-160523262 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Targeted
    6
  • Genomic Mutations
    2 involving Slamf6
  • Incidental Mutations
Mice homozygous for one null allele show no overt phenotype. Mice homozygous for another null allele show impaired IL-4 production by CD4+ T cells, reduced inflammatory response to L. mexicana infection, high susceptibility to S. typhimurium infection, and defective neutrophil bactericidal activity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050091 VEGA Gene Model | MGI Sequence Detail 35656 C57BL/6J ±  kb
transcript OTTMUST00000127385 VEGA | MGI Sequence Detail 5729 Not Applicable  
polypeptide OTTMUSP00000068736 VEGA | MGI Sequence Detail 351 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    239 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
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  • All nucleic 23
    cDNA 22
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 38
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:60849 Peck SR, et al., Ly108: a new member of the mouse CD2 family of cell surface proteins. Immunogenetics. 2000 Nov;52(1-2):63-72
  • Latest
    J:203566 Keszei M, et al., Expansion of an osteopontin-expressing T follicular helper cell subset correlates with autoimmunity in B6.Sle1b mice and is suppressed by the H1-isoform of the Slamf6 receptor. FASEB J. 2013 Aug;27(8):3123-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory