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Slamf6
Gene Detail
 Symbol
Name
ID
Slamf6
SLAM family member 6
MGI:1353620
Synonyms KAL1, KAL1b, Ly108, NTB-A, SF2000
Feature Type protein coding gene
Genetic Map
Chromosome 1
79.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:171917537-171943868 bp, + strand
From NCBI annotation of GRCm38

  26332 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:49945  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Slamf6
Human
homologs
Human Homolog SLAMF6, SLAM family member 6
NCBI Gene ID 114836
neXtProt AC  NX_Q96DU3
Human Synonyms  CD352, KALI, KALIb, Ly108, NTBA, NTB-A, SF2000
Human Chr (Location)  1q23.2; chr1:160454820-160493052 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(4) : Targeted(4)
 
Mice homozygous for one null allele show no overt phenotype. Mice homozygous for another null allele show impaired IL-4 production by CD4+ T cells, reduced inflammatory response to L. mexicana infection, high susceptibility to S. typhimurium infection, and defective neutrophil bactericidal activity.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (6 annotations)
Component integral to membrane, integral to plasma membrane, ...
Function receptor activity
External Resources: FuncBase
Expression cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(35) cDNA(34) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000015314 (Evidence)
Entrez Gene30925 (Evidence)
UniGene245727
DFCITC1585960, TC1590822, TC1608046, TC1628067
DoTSDT.528075, DT.55144931, DT.99856506
NIA Mouse Gene IndexU001099
Consensus CDS ProjectCCDS15504.1
International Mouse Knockout Project StatusSlamf6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 30925 NCBI Gene Model | MGI Sequence Detail 26332 C57BL/6J ±  kb
transcript NM_030710 RefSeq | MGI Sequence Detail 2443 C57BL/6 
polypeptide Q9ET39 UniProt | EBI | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(6)
Polymorphisms PCR(1) : SNPs(103 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR015631 Signalling lymphocyte activation molecule family receptors
Protein Ontology PR:000014913 SLAM family member 6
Graphical View of Protein Domain Structure
References (Earliest) J:60849 Peck SR, et al., Ly108: a new member of the mouse CD2 family of cell surface proteins. Immunogenetics. 2000 Nov;52(1-2):63-72
(Latest) J:193308 Dutta M, et al., A role for ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes. J Immunol. 2013 Mar 1;190(5):2121-8
All references(39)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory