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Slamf6
Gene Detail
Symbol

Name
ID
Slamf6
SLAM family member 6
MGI:1353620
Synonyms
KAL1, KAL1b, Ly108, NTB-A, SF2000
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:171917515-171953170 bp, + strand
From VEGA annotation of GRCm38

  35656 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49945  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SLAMF6
Gene Tree: Slamf6

Human
homologs
SLAMF6, SLAM family member 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 114836
neXtProt AC: NX_Q96DU3

Human Synonyms: CD352, KALI, KALIb, Ly108, NTBA, NTB-A, SF2000

Human Chr (Location): 1q23.2; chr1:160485030-160523262 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for one null allele show no overt phenotype. Mice homozygous for another null allele show impaired IL-4 production by CD4+ T cells, reduced inflammatory response to L. mexicana infection, high susceptibility to S. typhimurium infection, and defective neutrophil bactericidal activity.
 
Interactions
Slamf6 interacts with 230 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Component extracellular exosome, integral component of membrane, ...
Function receptor activity
External Resources: FuncBase
Expression
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000050091 (Evidence)
Ensembl Gene Model ENSMUSG00000015314 (Evidence)
Entrez Gene 30925 (Evidence)
UniGene 486404
DFCI TC1585960, TC1590822, TC1608046, TC1628067
DoTS DT.528075, DT.55144931, DT.99856506
NIA Mouse Gene Index U001099
Consensus CDS Project CCDS15504.1
International Mouse Phenotyping Consortium Status Slamf6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050091 VEGA Gene Model | MGI Sequence Detail 35656 C57BL/6J ±  kb
transcript OTTMUST00000127385 VEGA | MGI Sequence Detail 5729 Not Applicable 
polypeptide OTTMUSP00000068736 VEGA | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(15) UniProt(7)
Polymorphisms
PCR(1) : SNPs within 2kb(249 from dbSNP Build 137)    SNPs within 2kb including multiple locations(251)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set domain
InterPro IPR015631 Signalling lymphocyte activation molecule family receptors
Protein Ontology PR:000014913 SLAM family member 6
References
(Earliest) J:60849 Peck SR, et al., Ly108: a new member of the mouse CD2 family of cell surface proteins. Immunogenetics. 2000 Nov;52(1-2):63-72
(Latest) J:203566 Keszei M, et al., Expansion of an osteopontin-expressing T follicular helper cell subset correlates with autoimmunity in B6.Sle1b mice and is suppressed by the H1-isoform of the Slamf6 receptor. FASEB J. 2013 Aug;27(8):3123-31
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory