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Slamf6
Gene Detail
 Symbol
Name
ID
Slamf6
SLAM family member 6
MGI:1353620
Synonyms KAL1, KAL1b, Ly108, NTB-A, SF2000
Feature Type protein coding gene
Genetic Map
Chromosome 1
79.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:171917537-171943868 bp, + strand
From NCBI annotation of GRCm38

  26332 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49945  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Slamf6

Human
homologs
Human Homolog SLAMF6, SLAM family member 6
NCBI Gene ID 114836
neXtProt AC  NX_Q96DU3
Human Synonyms  CD352, KALI, KALIb, Ly108, NTBA, NTB-A, SF2000
Human Chr (Location)  1q23.2; chr1:160485030-160523262 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one null allele show no overt phenotype. Mice homozygous for another null allele show impaired IL-4 production by CD4+ T cells, reduced inflammatory response to L. mexicana infection, high susceptibility to S. typhimurium infection, and defective neutrophil bactericidal activity.
 
Interactions
Slamf6 interacts with 231 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Component extracellular vesicular exosome, integral component of membrane, ...
Function receptor activity
External Resources: FuncBase
Expression
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000015314 (Evidence)
Entrez Gene30925 (Evidence)
UniGene486404
DFCITC1585960, TC1590822, TC1608046, TC1628067
DoTSDT.528075, DT.55144931, DT.99856506
NIA Mouse Gene IndexU001099
Consensus CDS ProjectCCDS15504.1
International Mouse Knockout Project StatusSlamf6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 30925 NCBI Gene Model | MGI Sequence Detail 26332 C57BL/6J ±  kb
transcript NM_030710 RefSeq | MGI Sequence Detail 2443 C57BL/6 
polypeptide Q9ET39 UniProt | EBI | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(13) UniProt(6)
Polymorphisms PCR(1) : SNPs within 2kb(174 from dbSNP Build 137)    SNPs within 2kb including multiple locations(176)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR015631 Signalling lymphocyte activation molecule family receptors
Protein Ontology PR:000014913 SLAM family member 6
Graphical View of Protein Domain Structure
References (Earliest) J:60849 Peck SR, et al., Ly108: a new member of the mouse CD2 family of cell surface proteins. Immunogenetics. 2000 Nov;52(1-2):63-72
(Latest) J:203566 Keszei M, et al., Expansion of an osteopontin-expressing T follicular helper cell subset correlates with autoimmunity in B6.Sle1b mice and is suppressed by the H1-isoform of the Slamf6 receptor. FASEB J. 2013 Aug;27(8):3123-31
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory