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Adamts5
Gene Detail
 Symbol
Name
ID
Adamts5
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
MGI:1346321
Synonyms 9530092O11Rik, ADAM-TS5
Feature Type protein coding gene
Genetic Map
Chromosome 16
48.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:85858170-85901125 bp, - strand
From Ensembl annotation of GRCm38

  42956 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:5109  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Adamts5
Human
homologs
Human Homolog ADAMTS5, ADAM metallopeptidase with thrombospondin type 1 motif, 5
NCBI Gene ID 11096
neXtProt AC  NX_Q9UNA0
Human Synonyms  ADAMTS11, ADAM-TS 11, ADAMTS-11, ADAM-TS5, ADAM-TS 5, ADAMTS-5, ADMP-2
Human Chr (Location)  21q21.3; chr21:28290231-28339439 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(8) : Targeted(7) Gene trapped(1)
 
Mice homozygous for one null allele exhibit a significant reduction in cartilage degradation after induction of osteoarthritis whereas those homozygous for another show no affect.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (15 annotations)
Process metabolic process, proteolysis
Component cytoplasm, extracellular matrix, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression Literature Summary: (21 records)
Data Summary: Results (377)    Tissues (274)    Images (113)
Theiler Stages: 10, 11, 13, 15, 17, 18, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 202
In situ reporter (knock in) 111
Northern blot 4
RT-PCR 60
cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(27) cDNA(21) Primer pair(5) Other(1)
Microarray probesets(10)
Other database
links
Ensembl Gene ModelENSMUSG00000022894 (Evidence)
Entrez Gene23794 (Evidence)
DFCITC1584498, TC1598269, TC1618555
DoTSDT.91284377
NIA Mouse Gene IndexU017330, U037244
EC3.4.24.-
Consensus CDS ProjectCCDS28288.1
International Mouse Knockout Project StatusAdamts5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022894 Ensembl Gene Model | MGI Sequence Detail 42956 C57BL/6J ±  kb
transcript ENSMUST00000023611 Ensembl | MGI Sequence Detail 8091 Not Applicable 
polypeptide ENSMUSP00000023611 Ensembl | MGI Sequence Detail 930 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs(201 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR010294 ADAM-TS Spacer 1
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR013273 Peptidase M12B, ADAM-TS
InterPro IPR013276 Peptidase M12B, ADAM-TS5
InterPro IPR002870 Peptidase M12B, propeptide
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000003734 A disintegrin and metalloproteinase with thrombospondin motifs 5
References (Earliest) J:56831 Abbaszade I, et al., Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. J Biol Chem. 1999 Aug 13;274(33):23443-50
(Latest) J:195050 Wilson CL, et al., Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev. 2013 Apr-May;130(4-5):272-89
All references(62)
Other
accession IDs 		MGI:1925767, MGI:2146445
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/05/2013
MGI 5.13 		The Jackson Laboratory