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Scn11a Gene Detail
Summary
  • Symbol
    Scn11a
  • Name
    sodium channel, voltage-gated, type XI, alpha
  • Synonyms
    NaN, NaT, NSS2, SNS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345149
    NCBI Gene: 24046
  • Gene Overview
    MyGene.info: SCN11A
Location & Maps
more
  • Sequence Map
    Chr9:119753763-119825456 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      71694 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 71.33 cM, cytoband F3-F4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SCN11A, sodium voltage-gated channel alpha subunit 11
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SCN11A, sodium voltage-gated channel alpha subunit 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FEPS3, HSAN7, NaN, NAV1.9, PN5, SCN12A, SNS-2
  • Links
    NCBI Gene ID: 11280
    neXtProt AC: NX_Q9UI33

  • Chr Location
    3p22.2; chr3:38845769-38953651 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Scn11a mouse models; 2 with human SCN11A associations

Human Disease Mouse Models
       Neuropathy, Hereditary Sensory and Autonomic, Type VII; HSAN7   OMIM: 615548 View 1 model
       Episodic Pain Syndrome, Familial, 3; FEPS3   OMIM: 615552
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 6 alleles in 6 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous and heterozygous for one null allele display decreased duration of inflammation induced thermal hyperalgesia and decreased late phase pain responses to inflammatory stimuli. Mice homozygous for a second allele appear normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034115 Ensembl Gene Model | MGI Sequence Detail 71694 C57BL/6J ±  kb
transcript ENSMUST00000070617 Ensembl | MGI Sequence Detail 5837 Not Applicable  
polypeptide ENSMUSP00000065466 Ensembl | MGI Sequence Detail 1765 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    772 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000002097 sodium channel protein type 11 subunit alpha
  • InterPro Domains
    IPR005821 Ion transport domain
    IPR010526 Sodium ion transport-associated
    IPR027359 Voltage-dependent channel, four helix bundle domain
    IPR028821 Voltage gated sodium channel, alpha-11 subunit
    IPR001696 Voltage gated sodium channel, alpha subunit
Molecular
Reagents
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  • All nucleic 11
    cDNA 7
    Primer pair 4

    Microarray probesets 2
References
more
  • Summaries
    All 51
    Developmental Gene Expression 12
    Diseases 1
    Gene Ontology 7
    Phenotypes 18
  • Earliest
    J:57019 Dib-Hajj SD, et al., Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN. Genomics. 1999 Aug 1;59(3):309-18
  • Latest
    J:231602 Hockley JR, et al., P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors. J Neurosci. 2016 Feb 24;36(8):2364-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory