Ikzf1 MGI Mouse Gene Detail - MGI:1342540 - IKAROS family zinc finger 1

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Ikzf1 Gene Detail

Symbol

Ikzf1
Name

IKAROS family zinc finger 1
Synonyms

5832432G11Rik, Ikaros, LyF-1, Zfpn1a1

Feature Type

protein coding gene
IDs

MGI:1342540
NCBI Gene: 22778
Alliance

gene page
Transcription Start Sites

31 TSS

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Sequence Map

Chr11:11634980-11722926 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 7.02 cM
Mapping Data

5 experiments

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SNPs within 2kb

456 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1342540	protein coding gene	Chr11:11634970-11722930 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018045	protein coding gene	Chr11:8972697-9065587 (+)
A/J	MGP_AJ_G0018018	protein coding gene	Chr11:8658286-8748215 (+)
AKR/J	MGP_AKRJ_G0017982	protein coding gene	Chr11:9026632-9115976 (+)
BALB/cJ	MGP_BALBcJ_G0017986	protein coding gene	Chr11:8680144-8769714 (+)
C3H/HeJ	MGP_C3HHeJ_G0017799	protein coding gene	Chr11:8926218-9016947 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018438	protein coding gene	Chr11:9275692-9373430 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016096	protein coding gene	Chr11:8201342-8290450 (+)
CAST/EiJ	MGP_CASTEiJ_G0017361	protein coding gene	Chr11:8930270-9026820 (+)
CBA/J	MGP_CBAJ_G0017774	protein coding gene	Chr11:9952469-10046366 (+)
DBA/2J	MGP_DBA2J_G0017884	protein coding gene	Chr11:8593092-8681591 (+)
FVB/NJ	MGP_FVBNJ_G0017876	protein coding gene	Chr11:8502559-8592282 (+)
LP/J	MGP_LPJ_G0017955	protein coding gene	Chr11:9081677-9170878 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017902	protein coding gene	Chr11:9667747-9772707 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018479	protein coding gene	Chr11:9042195-9136944 (+)
PWK/PhJ	MGP_PWKPhJ_G0017141	protein coding gene	Chr11:8623937-8716563 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016938	protein coding gene	Chr11:8887573-8980929 (+)
WSB/EiJ	MGP_WSBEiJ_G0017415	protein coding gene	Chr11:8806352-8899248 (+)

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Human Ortholog

IKZF1, IKAROS family zinc finger 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IKZF1, IKAROS family zinc finger 1
Synonyms

CVID13, Hs.54452, IK1, IKAROS, LyF-1, LYF1, PPP1R92, PRO0758, ZNFN1A1
Links

HGNC:13176

NCBI Gene ID: 10320

neXtProt AC: NX_Q13422

UniProt: Q13422
Chr Location

7p12.2; chr7:50303455-50405101 (+) GRCh38

MGI Vertebrate Homology

Ikzf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IKZF1
Gene Tree

Ikzf1

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Diseases

4 with human IKZF1 associations

Human Disease

Mouse Models

Human gene associated with disease

acute lymphoblastic leukemia

IDs

View 1 model

B-lymphoblastic leukemia/lymphoma

IDs

colorectal cancer

IDs

common variable immunodeficiency 13

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

127 phenotypes from 11 alleles in 15 genetic backgrounds
21 phenotypes from multigenic genotypes
97 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (ENU)

5
Endonuclease-mediated

1
Gene trapped

1
Targeted

14
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants have a variety of T, B, and hematopoeitic cell maturation defects. Heterozygotes for one allele exhibit dominant negative effects and mice develop lymphoproliferative disorders.

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All GO Annotations

74
GO References

23

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1001
Tissues

182
cDNA Data

70
Literature Summary

46

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA IKZF1

Xenbase ikzf1

ZFIN ikzf1

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All Sequences

252
RefSeq

176
UniProt

13
CCDS

CCDS24436.1, CCDS24437.1

Ensembl

ENSMUSG00000018654 (Evidence)
NCBI Gene

22778

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000018654	Ensembl Gene Model \| MGI Sequence Detail	87947	C57BL/6J	± kb
	transcript	ENSMUST00000065433	Ensembl \| MGI Sequence Detail	4697	Not Applicable
	polypeptide	ENSMUSP00000067372	Ensembl \| MGI Sequence Detail	535	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000001811 DNA-binding protein Ikaros

(term hierarchy)
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 84

Genomic 1

cDNA 71

Primer pair 8

Other 4

Microarray probesets 7

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MGD-MRK-11345, MGI:2442667, MGI:96535

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Summaries

All 221

Developmental Gene Expression 46

Diseases 1

Gene Ontology 23

Phenotypes 97
Earliest

J:12906 Georgopoulos K, et al., Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science. 1992 Oct 30;258(5083):808-12
Latest

J:343294 Hu Y, et al., Lineage-specific 3D genome organization is assembled at multiple scales by IKAROS. Cell. 2023 Nov 22;186(24):5269-5289.e22

TSS for Ikzf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100355	Chr11:11634950-11634955 (+)	-27 bp
Tssr100356	Chr11:11634967-11635027 (+)	17 bp
Tssr100357	Chr11:11635542-11635553 (+)	568 bp
Tssr100358	Chr11:11635675-11635742 (+)	729 bp
Tssr3428	Chr11:11635906-11635907 (+)	927 bp
Tssr100359	Chr11:11635909-11635947 (+)	948 bp
Tssr100360	Chr11:11636215-11636282 (+)	1,269 bp
Tssr100361	Chr11:11636297-11636322 (+)	1,330 bp
Tssr100362	Chr11:11636398-11636403 (+)	1,421 bp
Tssr100363	Chr11:11637717-11637732 (+)	2,745 bp
Tssr100364	Chr11:11637747-11637756 (+)	2,772 bp
Tssr100365	Chr11:11639944-11639947 (+)	4,966 bp
Tssr100366	Chr11:11640078-11640079 (+)	5,099 bp
Tssr100367	Chr11:11640082-11640103 (+)	5,113 bp
Tssr100368	Chr11:11640114-11640135 (+)	5,145 bp
Tssr100369	Chr11:11640137-11640184 (+)	5,181 bp
Tssr100370	Chr11:11640185-11640197 (+)	5,211 bp
Tssr100371	Chr11:11640202-11640213 (+)	5,228 bp
Tssr100372	Chr11:11640267-11640280 (+)	5,294 bp
Tssr100373	Chr11:11640291-11640312 (+)	5,322 bp
Tssr100374	Chr11:11640313-11640329 (+)	5,341 bp
Tssr100375	Chr11:11640408-11640421 (+)	5,435 bp
Tssr100376	Chr11:11640449-11640468 (+)	5,479 bp
Tssr100380	Chr11:11651642-11651644 (+)	16,663 bp
Tssr100381	Chr11:11669762-11669776 (+)	34,789 bp
Tssr100382	Chr11:11691843-11691858 (+)	56,871 bp
Tssr100383	Chr11:11694127-11694130 (+)	59,149 bp
Tssr100384	Chr11:11715077-11715082 (+)	80,100 bp
Tssr100385	Chr11:11719183-11719185 (+)	84,204 bp
Tssr100386	Chr11:11719553-11719565 (+)	84,579 bp
Tssr100387	Chr11:11721444-11721457 (+)	86,471 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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