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Mlf1 Gene Detail
Summary
  • Symbol
    Mlf1
  • Name
    myeloid leukemia factor 1
  • Synonyms
    HLS7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341819
    NCBI Gene: 17349
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:67281430-67307333 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 30.91 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341819
 protein coding gene Chr3:67281430-67307336 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027279
 protein coding gene Chr3:66527076-66556804 (+)
A/J MGP_AJ_G0027241
 protein coding gene Chr3:64576272-64605675 (+)
AKR/J MGP_AKRJ_G0027209
 protein coding gene Chr3:65944575-65973106 (+)
BALB/cJ MGP_BALBcJ_G0027252
 protein coding gene Chr3:64437422-64464588 (+)
C3H/HeJ MGP_C3HHeJ_G0026996
 protein coding gene Chr3:66202060-66228050 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027698
 protein coding gene Chr3:69025044-69053735 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025051
 protein coding gene Chr3:60913434-60939971 (+)
CAST/EiJ MGP_CASTEiJ_G0026443
 protein coding gene Chr3:66144556-66175695 (+)
CBA/J MGP_CBAJ_G0026971
 protein coding gene Chr3:71161774-71196267 (+)
DBA/2J MGP_DBA2J_G0027107
 protein coding gene Chr3:64074827-64103764 (+)
FVB/NJ MGP_FVBNJ_G0027075
 protein coding gene Chr3:62712817-62738680 (+)
LP/J MGP_LPJ_G0027215
 protein coding gene Chr3:67463510-67492758 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027094
 protein coding gene Chr3:75829921-75862260 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027756
 protein coding gene Chr3:65838752-65865302 (+)
PWK/PhJ MGP_PWKPhJ_G0026177
 protein coding gene Chr3:63825034-63852213 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025993
 protein coding gene Chr3:64958274-64983963 (+)
WSB/EiJ MGP_WSBEiJ_G0026521
 protein coding gene Chr3:65946133-65974745 (+)



Homology
more
  • Human Ortholog
    MLF1, myeloid leukemia factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MLF1, myeloid leukemia factor 1
  • Links
    NCBI Gene ID: 4291
    neXtProt AC: NX_P58340
    UniProt: P58340

  • Chr Location
    3q25.32; chr3:158571163-158607252 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Mlf1
  • Find Mice (IMSR)
    19 strains or lines available
Mice homozygous for a null allele exhibit a slight increased B cells in the spleen and decreased ex vivo thymocyte apoptosis susceptibility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    25
  • cDNA Data
    70
  • Literature Summary
    12
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17349 NCBI Gene Model | MGI Sequence Detail 25904 C57BL/6J ±  kb
transcript NM_001039543 RefSeq | MGI Sequence Detail 1178 ZRU/MplStud  
polypeptide Q9QWV4 UniProt | EBI | MGI Sequence Detail 267 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 70
    cDNA 70

    Microarray probesets 3
References
more
  • Summaries
    All 48
    Developmental Gene Expression 12
    Diseases 1
    Gene Ontology 11
    Phenotypes 9
  • Earliest
    J:56033 Hitzler JK, et al., cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia. Am J Pathol. 1999 Jul;155(1):53-9
  • Latest
    J:298990 Sah RK, et al., Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality. Int J Mol Sci. 2020 Nov 3;21(21):8223
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory