About   Help   FAQ
P2rx7
Gene Detail
 Symbol
Name
ID
P2rx7
purinergic receptor P2X, ligand-gated ion channel, 7
MGI:1339957
Synonyms P2X(7), P2X7R, P2X7 receptor
Feature Type protein coding gene
Genetic Map
Chromosome 5
62.50 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:122643911-122691432 bp, + strand
From VEGA annotation of GRCm38

  47522 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:1925  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: P2rx7
Human
homologs
Human Homolog P2RX7, purinergic receptor P2X, ligand-gated ion channel, 7
NCBI Gene ID 5027
neXtProt AC  NX_Q99572
Human Synonyms  P2X7
Human Chr (Location)  12q24; chr12:121570622-121624354 (+)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(9) : Targeted(7) Gene trapped(1) Spontaneous(1)
 
Mice homozygous for disruptions in this gene are fertile and viable with no obvious phenotypic abnormality. Cellular responses of macrophages to extracellular ATP are frequently normal however. In addition, long bones are thinner than normal in adult mice.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (148 annotations)
Process activation of MAPK activity, bleb assembly, ...
Component bleb, cell-cell junction, ...
Function ATP binding, channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Results (7)    Tissues (4)    Images (2)
Theiler Stages: 22, 25, 28
Assay TypeResults
RT-PCR 7
cDNA source data(29)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents 		All nucleic(32) cDNA(30) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000026740 (Evidence)
Ensembl Gene ModelENSMUSG00000029468 (Evidence)
Entrez Gene18439 (Evidence)
UniGene42026
DFCITC1585870, TC1588530, TC1589640, TC1625377
DoTSDT.101355105, DT.91336254, DT.94273607, DT.94391133, DT.99849462
NIA Mouse Gene IndexU042686
Consensus CDS ProjectCCDS19651.1, CCDS19652.1, CCDS19653.1, CCDS51644.1
International Mouse Knockout Project StatusP2rx7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026740 VEGA Gene Model | MGI Sequence Detail 47522 C57BL/6J ±  kb
transcript OTTMUST00000066137 VEGA | MGI Sequence Detail 4936 Not Applicable 
polypeptide OTTMUSP00000033090 VEGA | MGI Sequence Detail 595 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(8) UniProt(11)
Polymorphisms SNPs(330 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR003050 P2X7 purinoceptor
InterPro IPR001429 P2X purinoreceptor
Protein Ontology PR:000012194 P2X purinoceptor 7
References (Earliest) J:51040 Chessell IP, et al., Cloning and functional characterisation of the mouse P2X7 receptor. FEBS Lett. 1998 Nov 13;439(1-2):26-30
(Latest) J:193771 Deplano S, et al., P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis. J Leukoc Biol. 2013 Jan;93(1):127-34
All references(193)
Other
accession IDs 		MGI:2140909
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory