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Adamts4
Gene Detail
 Symbol
Name
ID
Adamts4
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
MGI:1339949
Synonyms ADAM-TS4, aggrecanase-1
Feature Type protein coding gene
Genetic Map
Chromosome 1
79.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:171250421-171260637 bp, + strand
From VEGA annotation of GRCm38

  10217 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:36169  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Adamts4
Human
homologs
Human Homolog ADAMTS4, ADAM metallopeptidase with thrombospondin type 1 motif, 4
NCBI Gene ID 9507
neXtProt AC  NX_O75173
Human Synonyms  ADAMTS-2, ADAMTS-4, ADMP-1
Human Chr (Location)  1q21-q23; chr1:161159538-161168845 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(20) : Targeted(10) Gene trapped(10)
 
Homozygous mutant mice do not exhibit any morphological abnormalities. However, they do display impaired coordination and an increased susceptibility to pharmacologically induced seizures.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications 		All GO classifications: (14 annotations)
Process proteolysis
Component extracellular matrix, extracellular region, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression Literature Summary: (13 records)
Data Summary: Results (130)    Tissues (85)    Images (45)
Theiler Stages: 11, 23, 25, 28
Assay TypeResults
RNA in situ 16
In situ reporter (knock in) 75
RT-PCR 39
cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(43) cDNA(41) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021528 (Evidence)
Ensembl Gene ModelENSMUSG00000006403 (Evidence)
Entrez Gene240913 (Evidence)
UniGene485813
DFCITC1578134, TC1631971, TC1640871
DoTSDT.40142777, DT.97339683
NIA Mouse Gene IndexU001081
EC3.4.24.82
Consensus CDS ProjectCCDS15485.1
International Mouse Knockout Project StatusAdamts4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021528 VEGA Gene Model | MGI Sequence Detail 10217 C57BL/6J ±  kb
transcript OTTMUST00000051062 VEGA | MGI Sequence Detail 4389 Not Applicable 
polypeptide OTTMUSP00000023975 VEGA | MGI Sequence Detail 833 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(6)
Polymorphisms RFLP(1) : SNPs(64 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR010294 ADAM-TS Spacer 1
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR013273 Peptidase M12B, ADAM-TS
InterPro IPR002870 Peptidase M12B, propeptide
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000003733 A disintegrin and metalloproteinase with thrombospondin motifs 4
References (Earliest) J:55481 Tortorella MD, et al., Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins [see comments]. Science. 1999 Jun 4;284(5420):1664-6
(Latest) J:188497 Hisanaga A, et al., A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves Reelin in an isoform-dependent manner. FEBS Lett. 2012 Sep 21;586(19):3349-53
All references(53)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory