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Sema5a
Gene Detail
 Symbol
Name
ID
Sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
MGI:107556
Synonyms 9130201M22Rik, M-Sema D, Semaf, semF
Feature Type protein coding gene
Genetic Map
Chromosome 15
13.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:32244813-32696341 bp, + strand
From NCBI annotation of GRCm38

  451529 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:2949  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sema5a
Human
homologs
Human Homolog SEMA5A, sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
NCBI Gene ID 9037
neXtProt AC  NX_Q13591
Human Synonyms  SEMAF, semF
Human Chr (Location)  5p15.2; chr5:9035138-9546233 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(7) : Targeted(7)
 
Mice homozygous for one null mutation die during organogenesis and display defects in branching of cranial vessels. Mice homozygous for another null mutation appear normal.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (14 annotations)
Process axon guidance, branching morphogenesis of an epithelial tube, ...
Component integral to membrane, membrane
Function axon guidance receptor activity, receptor activity
External Resources: FuncBase
Expression Literature Summary: (22 records)
Data Summary: Results (547)    Tissues (416)    Images (103)
Theiler Stages: 11, 12, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 353
In situ reporter (knock in) 114
Northern blot 27
Western blot 14
RT-PCR 39
cDNA source data(63)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(72) cDNA(69) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022231 (Evidence)
Entrez Gene20356 (Evidence)
UniGene260374
DFCITC1585147, TC1587609, TC1599505, TC1656058, TC1669534
DoTSDT.110820940, DT.40179421, DT.87039503, DT.94251089
NIA Mouse Gene IndexU016139
Consensus CDS ProjectCCDS37055.1
International Mouse Knockout Project StatusSema5a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20356 NCBI Gene Model | MGI Sequence Detail 451529 C57BL/6J ±  kb
transcript NM_009154 RefSeq | MGI Sequence Detail 10809 C57BL/6 
polypeptide Q62217 UniProt | EBI | MGI Sequence Detail 1077 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(5)
Polymorphisms SNPs(2987 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR002165 Plexin
InterPro IPR016201 Plexin-like fold
InterPro IPR003659 Plexin/semaphorin/integrin
InterPro IPR027231 Semaphorin
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR000884 Thrombospondin, type 1 repeat
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000014627 semaphorin-5A
Graphical View of Protein Domain Structure
References (Earliest) J:28378 Inagaki S, et al., Identification of a member of mouse semaphorin family. FEBS Lett. 1995 Aug 21;370(3):269-72
(Latest) J:176977 Gunn RK, et al., Are Sema5a mutant mice a good model of autism? A behavioral analysis of sensory systems, emotionality and cognition. Behav Brain Res. 2011 Nov 20;225(1):142-50
All references(57)
Other
accession IDs 		MGD-MRK-36127, MGI:2146024, MGI:2445048
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/22/2013
MGI 5.13 		The Jackson Laboratory