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Cacna2d3
Gene Detail
 Symbol
Name
ID
Cacna2d3
calcium channel, voltage-dependent, alpha2/delta subunit 3
MGI:1338890
Synonyms alpha2delta3, alpha 2 delta-3
Feature Type protein coding gene
Genetic Map
Chromosome 14
16.80 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:28904947-29721864 bp, - strand
From Ensembl annotation of GRCm38

  816918 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:74929  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: voltage-dependent calcium channel fused subunit
Gene Tree: Cacna2d3
Human
homologs
Human Homolog CACNA2D3, calcium channel, voltage-dependent, alpha 2/delta subunit 3
NCBI Gene ID 55799
neXtProt AC  NX_Q8IZS8
Human Synonyms  HSA272268
Human Chr (Location)  3p21.1; chr3:54156693-55108584 (+)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(5) : Targeted(4) Gene trapped(1)
 
Mice homozygous for disruptions in this gene have a decreased startle reflex and occasional animals show increased aggression and hyperactivity.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (12 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component integral to membrane, membrane
Function calcium channel activity, ion channel activity, ...
External Resources: FuncBase
Expression Literature Summary: (7 records)
Data Summary: Results (257)    Tissues (69)    Images (34)
Theiler Stages: 23, 24, 25, 28
Assay TypeResults
RNA in situ 151
In situ reporter (knock in) 54
RT-PCR 52
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(20) cDNA(15) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021991 (Evidence)
Entrez Gene12294 (Evidence)
UniGene386754
DFCITC1585796
DoTSDT.87068382
NIA Mouse Gene IndexU035350
International Mouse Knockout Project StatusCacna2d3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021991 Ensembl Gene Model | MGI Sequence Detail 816918 C57BL/6J ±  kb
transcript ENSMUST00000022567 Ensembl | MGI Sequence Detail 3691 Not Applicable 
polypeptide ENSMUSP00000022567 Ensembl | MGI Sequence Detail 1091 Not Applicable 

For the selected sequences
All sequences(13) RefSeq(2) UniProt(1)
Polymorphisms SNPs(4699 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR004010 Cache domain
InterPro IPR002035 von Willebrand factor, type A
InterPro IPR013608 VWA N-terminal
Protein Ontology PR:000004944 voltage-dependent calcium channel subunit alpha-2/delta-3
References (Earliest) J:52012 Klugbauer N, et al., Molecular diversity of the calcium channel alpha2delta subunit. J Neurosci. 1999 Jan 15;19(2):684-91
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(35)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory