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Ncor2 Gene Detail
Summary
  • Symbol
    Ncor2
  • Name
    nuclear receptor co-repressor 2
  • Synonyms
    SMRT, SMRTe
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337080
    NCBI Gene: 20602
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:125094217-125256283 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.96 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    775 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337080
 protein coding gene Chr5:125094217-125256302 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030108
 protein coding gene Chr5:128823087-128995805 (-)
A/J MGP_AJ_G0030073
 protein coding gene Chr5:123443199-123606536 (-)
AKR/J MGP_AKRJ_G0030009
 protein coding gene Chr5:127431674-127599133 (-)
BALB/cJ MGP_BALBcJ_G0030084
 protein coding gene Chr5:124773480-124938134 (-)
C3H/HeJ MGP_C3HHeJ_G0029801
 protein coding gene Chr5:128032491-128208216 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030537
 protein coding gene Chr5:133816366-133987231 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027763
 protein coding gene Chr5:117979364-118142242 (-)
CAST/EiJ MGP_CASTEiJ_G0029210
 protein coding gene Chr5:127169468-127344955 (-)
CBA/J MGP_CBAJ_G0029771
 protein coding gene Chr5:139054016-139240724 (-)
DBA/2J MGP_DBA2J_G0029921
 protein coding gene Chr5:123461263-123624485 (-)
FVB/NJ MGP_FVBNJ_G0029877
 protein coding gene Chr5:122517396-122687679 (-)
LP/J MGP_LPJ_G0030010
 protein coding gene Chr5:129342421-129513907 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029908
 protein coding gene Chr5:142592024-142763331 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030578
 protein coding gene Chr5:127049321-127222064 (-)
PWK/PhJ MGP_PWKPhJ_G0028924
 protein coding gene Chr5:122292951-122462216 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028761
 protein coding gene Chr5:124684504-124848859 (-)
WSB/EiJ MGP_WSBEiJ_G0029284
 protein coding gene Chr5:127742344-127918298 (-)



Homology
more
  • Human Ortholog
    NCOR2, nuclear receptor corepressor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCOR2, nuclear receptor corepressor 2
  • Synonyms
    CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC1, TRAC-1
  • Links
    NCBI Gene ID: 9612
    neXtProt AC: NX_Q9Y618
    UniProt: Q9Y618

  • Chr Location
    12q24.31; chr12:124324415-124567612 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ncor2 mouse models; 1 with human NCOR2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 5 alleles in 5 genetic backgrounds
    10 phenotypes from multigenic genotypes
    8 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die before E16.5 of heart defects and exhibit neural defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    76
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    884
  • Tissues
    98
  • cDNA Data
    111
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029478 Ensembl Gene Model | MGI Sequence Detail 162067 C57BL/6J ±  kb
    transcript ENSMUST00000111402 Ensembl | MGI Sequence Detail 8862 Not Applicable  
    polypeptide ENSMUSP00000107033 Ensembl | MGI Sequence Detail 2507 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      cDNA 112
      Primer pair 4
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 25
      Phenotypes 45
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:333184 Lee RD, et al., Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation. Nat Immunol. 2022 Dec;23(12):1763-1776
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory