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Tnfsf8
Gene Detail
 Symbol
Name
ID
Tnfsf8
tumor necrosis factor (ligand) superfamily, member 8
MGI:88328
Synonyms CD153, Cd30L, CD30LG
Feature Type protein coding gene
Genetic Map
Chromosome 4
34.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:63831308-63861347 bp, - strand
From VEGA annotation of GRCm38

  30040 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:950  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: tumour necrosis factor family protein, CD30 ligand type
Gene Tree: Tnfsf8
Human
homologs
Human Homolog TNFSF8, tumor necrosis factor (ligand) superfamily, member 8
NCBI Gene ID 944
neXtProt AC  NX_P32971
Human Synonyms  CD153, CD30L, CD30LG
Human Chr (Location)  9q33; chr9:117655623-117692875 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(1) : Targeted(1)
 
Homozygous null mice diplay decreased susceptibility to graft versus host disease.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (11 annotations)
Process CD8-positive, alpha-beta T cell differentiation, defense response to Gram-positive bacterium, ...
Component extracellular space, integral to membrane, ...
Function cytokine activity, tumor necrosis factor receptor binding
External Resources: FuncBase
Expression Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 24
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(14) cDNA(12) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000000301 (Evidence)
Ensembl Gene ModelENSMUSG00000028362 (Evidence)
Entrez Gene21949 (Evidence)
DoTSDT.40175031, DT.91333433
Consensus CDS ProjectCCDS18264.1
International Mouse Knockout Project StatusTnfsf8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000301 VEGA Gene Model | MGI Sequence Detail 30040 C57BL/6J ±  kb
transcript OTTMUST00000000772 VEGA | MGI Sequence Detail 3807 Not Applicable 
polypeptide OTTMUSP00000000340 VEGA | MGI Sequence Detail 239 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(5) : PCR(1) RFLP(4) SNPs within 2kb(220 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006052 Tumour necrosis factor
InterPro IPR021184 Tumour necrosis factor, conserved site
InterPro IPR021185 Tumour necrosis factor family protein, CD30 ligand type
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000001404 tumor necrosis factor ligand superfamily member 8
References (Earliest) J:12921 Smith CA, et al., CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell. 1993 Jul 2;73(7):1349-60
(Latest) J:176802 Fuchiwaki T, et al., The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice. Eur J Immunol. 2011 Oct;41(10):2947-54
All references(39)
Other
accession IDs 		MGD-MRK-1847
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/12/2013
MGI 5.14 		The Jackson Laboratory