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Lrp5
Gene Detail
 Symbol
Name
ID
Lrp5
low density lipoprotein receptor-related protein 5
MGI:1278315
Synonyms LR3, LRP7
Feature Type protein coding gene
Genetic Map
Chromosome 19
3.33 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:3584828-3686564 bp, - strand
From VEGA annotation of GRCm38

  101737 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:1746  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: low density lipoprotein receptor-related protein, 5/6 types
Gene Tree: Lrp5
Human
homologs
Human Homolog LRP5, low density lipoprotein receptor-related protein 5
NCBI Gene ID 4041
neXtProt AC  NX_O75197
Human Synonyms  BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPS, OPTA1, VBCH2
Human Chr (Location)  11q13.4; chr11:68080108-68216743 (+)  GRCh37.p10
Disease Associations  (7) Diseases Associated with Human LRP5
Alleles
and
phenotypes 		All alleles(24) : Targeted(17) Gene trapped(6) Chemically induced(1)
 
Homozygous mutants show variable bone loss, decreased osteoblast proliferation, impaired glucose tolerance, increased plasma cholesterol on high-fat diet and persistent embryonic eye vascularization, depending on allelic combination and strain background.
 
Human Diseases Modeled Using Mouse Lrp5 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(5)
Gene Ontology
(GO)
classifications 		All GO classifications: (82 annotations)
Process adipose tissue development, anatomical structure regression, ...
Component endoplasmic reticulum, integral to membrane, ...
Function coreceptor activity, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (33 records)
Data Summary: Results (307)    Tissues (197)    Images (29)
Theiler Stages: 1, 2, 3, 4, 5, 10, 18, 19, 20, 22, 23, 25, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 198
Northern blot 12
RT-PCR 92
cDNA source data(81)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(89) Genomic(1) cDNA(81) Primer pair(6) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000042195 (Evidence)
Ensembl Gene ModelENSMUSG00000024913 (Evidence)
Entrez Gene16973 (Evidence)
UniGene274581
DFCITC1577532, TC1617568, TC1677577, TC1724610, TC1771917
DoTSDT.101238699, DT.101734904, DT.110864077, DT.481503, DT.91429993, DT.97369430
NIA Mouse Gene IndexU019112
Consensus CDS ProjectCCDS37881.1
International Mouse Knockout Project StatusLrp5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042195 VEGA Gene Model | MGI Sequence Detail 101737 C57BL/6J ±  kb
transcript OTTMUST00000110769 VEGA | MGI Sequence Detail 5161 Not Applicable 
polypeptide OTTMUSP00000061850 VEGA | MGI Sequence Detail 1614 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(2) UniProt(6)
Polymorphisms SNPs within 2kb(544 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000033 LDLR class B repeat
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR017049 Low density lipoprotein receptor-related protein, 5/6
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000009925 low-density lipoprotein receptor-related protein 5
References (Earliest) J:49544 Hey PJ, et al., Cloning of a novel member of the low-density lipoprotein receptor family. Gene. 1998 Aug 17;216(1):103-11
(Latest) J:194074 Ahn Y, et al., Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013 Feb 1;140(3):583-93
All references(109)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/12/2013
MGI 5.14 		The Jackson Laboratory