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Kcnn4
Gene Detail
 Symbol
Name
ID
Kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
MGI:1277957
Synonyms IK1, IKCa1, KCa3.1, mIKCa1, SK4
Feature Type protein coding gene
Genetic Map
Chromosome 7
10.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:24370263-24385209 bp, + strand
From Ensembl annotation of GRCm38

  14947 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:1696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Protein SuperFamily: small/intermediate conductance calcium-activated potassium channel protein
Gene Tree: Kcnn4
Human
homologs
Human Homolog KCNN4, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
NCBI Gene ID 3783
neXtProt AC  NX_O15554
Human Synonyms  hIKCa1, hKCa4, hSK4, IK1, IKCA1, KCa3.1, KCA4, SK4
Human Chr (Location)  19q13.2; chr19:44270685-44285409 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(4) : Targeted(4)
 
Homozygous null male mice have increased parotid gland weight and both sexes have impaired volume regulation in erythrocytes and T lymphocytes.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (31 annotations)
Process anion transport, calcium ion transport, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function calcium-activated potassium channel activity, calmodulin binding, ...
External Resources: FuncBase
Expression Literature Summary: (5 records)
Data Summary: Results (127)    Tissues (98)    Images (31)
Theiler Stages: 22, 23, 25, 28
Assay TypeResults
RNA in situ 124
RT-PCR 3
cDNA source data(240)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(243) cDNA(240) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000054342 (Evidence)
Entrez Gene16534 (Evidence)
UniGene9911
DFCITC1572747, TC1605977, TC1624856, TC1681805
DoTSDT.101283223, DT.101717966, DT.491549, DT.91429608, DT.94216600, DT.94216605
NIA Mouse Gene IndexU007794
Consensus CDS ProjectCCDS20948.1
International Mouse Knockout Project StatusKcnn4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054342 Ensembl Gene Model | MGI Sequence Detail 14947 C57BL/6J ±  kb
transcript ENSMUST00000171904 Ensembl | MGI Sequence Detail 2034 Not Applicable 
polypeptide ENSMUSP00000133065 Ensembl | MGI Sequence Detail 425 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(3)
Polymorphisms SNPs(124 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR004178 Calmodulin-binding domain
InterPro IPR013099 Ion transport 2
InterPro IPR015449 Potassium channel, calcium-activated, SK
Protein Ontology PR:000000700 intermediate conductance calcium-activated potassium channel protein 4
References (Earliest) J:49276 Vandorpe DH, et al., cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation. J Biol Chem. 1998 Aug 21;273(34):21542-53
(Latest) J:192205 Lambertsen KL, et al., Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels. PLoS One. 2012;7(10):e47744
All references(59)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory