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Pknox1
Gene Detail
 Symbol
Name
ID
Pknox1
Pbx/knotted 1 homeobox
MGI:1201409
Synonyms D17Wsu76e, PREP1
Feature Type protein coding gene
Genetic Map
Chromosome 17
16.78 cM, cytoband B-C
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr17:31564749-31607680 bp, + strand
From VEGA annotation of GRCm38

  42932 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:3363  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 3 zebrafish

Gene Tree: Pknox1
Human
homologs
Human Homolog PKNOX1, PBX/knotted 1 homeobox 1
NCBI Gene ID 5316
neXtProt AC  NX_P55347
Human Synonyms  pkonx1c, PREP1
Human Chr (Location)  21q22.3; chr21:44394643-44453688 (+)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(236) : Targeted(9) Gene trapped(227)
 
Homozygous mutation of this gene results in embryonic lethality during fetal growth and development with variable penetrance, decreased body weight, and impaired T cell development.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (22 annotations)
Process angiogenesis, camera-type eye development, ...
Component cytoplasm, nucleus, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression Literature Summary: (23 records)
Data Summary: Results (190)    Tissues (156)    Images (15)
Theiler Stages: 2, 3, 4, 5, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 109
Northern blot 1
Western blot 9
RT-PCR 39
RNase protection 20
cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(24) Genomic(2) cDNA(16) Primer pair(6)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000040106 (Evidence)
Ensembl Gene ModelENSMUSG00000006705 (Evidence)
Entrez Gene18771 (Evidence)
DFCITC1580994, TC1613380, TC1635220
DoTSDT.110556564, DT.490209, DT.97362547, DT.97365895
NIA Mouse Gene IndexU043583
Consensus CDS ProjectCCDS28608.1
International Mouse Knockout Project StatusPknox1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040106 VEGA Gene Model | MGI Sequence Detail 42932 C57BL/6J ±  kb
transcript OTTMUST00000104191 VEGA | MGI Sequence Detail 2283 Not Applicable 
polypeptide OTTMUSP00000058285 VEGA | MGI Sequence Detail 436 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(3) UniProt(1)
Polymorphisms SNPs(102 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000012788 homeobox protein PKNOX1
References (Earliest) J:45106 Knoepfler PS, et al., Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14553-8
(Latest) J:192251 Iotti G, et al., Reduction of Prep1 levels affects differentiation of normal and malignant B cells and accelerates Myc driven lymphomagenesis. PLoS One. 2012;7(10):e48353
All references(80)
Other
accession IDs 		MGD-MRK-33976, MGI:106284
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/05/2013
MGI 5.13 		The Jackson Laboratory