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Top3a Gene Detail
Summary
  • Symbol
    Top3a
  • Name
    topoisomerase (DNA) III alpha
  • Synonyms
    Top IIIa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197527
    NCBI Gene: 21975
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:60630884-60668191 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.81 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    446 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197527
 protein coding gene Chr11:60629035-60668191 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018424
 protein coding gene Chr11:60654591-60696261 (-)
A/J MGP_AJ_G0018393
 protein coding gene Chr11:58423153-58462306 (-)
AKR/J MGP_AKRJ_G0018363
 protein coding gene Chr11:60276578-60313690 (-)
BALB/cJ MGP_BALBcJ_G0018364
 protein coding gene Chr11:58720019-58757807 (-)
C3H/HeJ MGP_C3HHeJ_G0018177
 protein coding gene Chr11:60211888-60252957 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018816
 protein coding gene Chr11:62575537-62618018 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016462
 protein coding gene Chr11:55565805-55600747 (-)
CAST/EiJ MGP_CASTEiJ_G0017734
 protein coding gene Chr11:60309601-60351337 (-)
CBA/J MGP_CBAJ_G0018151
 protein coding gene Chr11:65301267-65342128 (-)
DBA/2J MGP_DBA2J_G0018260
 protein coding gene Chr11:58009607-58047115 (-)
FVB/NJ MGP_FVBNJ_G0018251
 protein coding gene Chr11:57671568-57710259 (-)
LP/J MGP_LPJ_G0018333
 protein coding gene Chr11:61235293-61273461 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018275
 protein coding gene Chr11:66354278-66405279 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018857
 protein coding gene Chr11:60368121-60408510 (-)
PWK/PhJ MGP_PWKPhJ_G0017507
 protein coding gene Chr11:58587589-58627170 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017297
 protein coding gene Chr11:60183994-60222594 (-)
WSB/EiJ MGP_WSBEiJ_G0017786
 protein coding gene Chr11:59988928-60028020 (-)



Homology
more
  • Human Ortholog
    TOP3A, DNA topoisomerase III alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOP3A, DNA topoisomerase III alpha
  • Synonyms
    MGRISCE2, PEOB5, TOP3, ZGRF7
  • Links
    NCBI Gene ID: 7156
    neXtProt AC: NX_Q13472
    UniProt: Q13472

  • Chr Location
    17p11.2; chr17:18271428-18315007 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TOP3A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die shortly after implantation and the induction of decidual reaction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    779
  • Tissues
    65
  • cDNA Data
    17
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002814 Ensembl Gene Model | MGI Sequence Detail 37308 C57BL/6J ±  kb
transcript ENSMUST00000002891 Ensembl | MGI Sequence Detail 3741 Not Applicable  
polypeptide ENSMUSP00000002891 Ensembl | MGI Sequence Detail 1003 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    Genomic 4
    cDNA 17
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 57
    Developmental Gene Expression 6
    Diseases 2
    Gene Ontology 8
    Phenotypes 23
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory