About   Help   FAQ
Thbs4
Gene Detail
 Symbol
Name
ID
Thbs4
thrombospondin 4
MGI:1101779
Synonyms TSP4, TSP-4
Feature Type protein coding gene
Genetic Map
Chromosome 13
47.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:92751590-92794818 bp, - strand
From VEGA annotation of GRCm38

  43229 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20691  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: thrombospondin 3
Gene Tree: Thbs4

Human
homologs
Human Homolog THBS4, thrombospondin 4
NCBI Gene ID 7060
neXtProt AC  NX_P35443
Human Synonyms  TSP4
Human Chr (Location)  5q13; chr5:80035347-80083287 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit increased sensitivity to cardiac pressure overload, including increased hypertrophy, decreased ejection fraction, decreased microvessle number, increased extracellular matrix deposition and increased fibrosis.
 
Interactions
Thbs4 interacts with 81 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process behavioral response to pain, cell adhesion, ...
Component basement membrane, endoplasmic reticulum, ...
Function calcium ion binding, collagen binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (314)    Tissues (70)    Images (61)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 237
In situ reporter (knock in) 39
RT-PCR 38
cDNA source data(32)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(33) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036725 (Evidence)
Ensembl Gene ModelENSMUSG00000021702 (Evidence)
Entrez Gene21828 (Evidence)
UniGene20865
DFCITC1580565
DoTSDT.526185
NIA Mouse Gene IndexU035026
Consensus CDS ProjectCCDS26684.1
International Mouse Knockout Project StatusThbs4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036725 VEGA Gene Model | MGI Sequence Detail 43229 C57BL/6J ±  kb
transcript OTTMUST00000094148 VEGA | MGI Sequence Detail 3198 Not Applicable 
polypeptide OTTMUSP00000052302 VEGA | MGI Sequence Detail 963 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(276 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR001791 Laminin G domain
InterPro IPR024665 Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
InterPro IPR008859 Thrombospondin, C-terminal
InterPro IPR003367 Thrombospondin, type 3-like repeat
InterPro IPR017897 Thrombospondin, type 3 repeat
Protein Ontology PR:000000132 thrombospondin-4
References (Earliest) J:44447 Baumeister A, et al., Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis. J Cell Biol. 1997 Dec 1;139(5):1231-42
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory