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Capn5
Gene Detail
 Symbol
Name
ID
Capn5
calpain 5
MGI:1100859
Feature Type protein coding gene
Genetic Map
Chromosome 7
53.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:98121559-98178274 bp, - strand
From VEGA annotation of GRCm38

  56716 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31212  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Capn5

Human
homologs
Human Homolog CAPN5, calpain 5
NCBI Gene ID 726
neXtProt AC  NX_O15484
Human Synonyms  ADNIV, HTRA3, nCL-3, VRNI
Human Chr (Location)  11q14; chr11:77066945-77126155 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CAPN5
Alleles
and
phenotypes
All alleles(31) : Targeted(4) Gene trapped(27)
 
Mice homozygous for one allele of this gene occasionally exhibit reduced viability but are usually normal. Homozygotes for another allele die as embryos.
 
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process proteolysis
Component cell surface, cytoplasm, ...
Function calcium-dependent cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (162)    Tissues (87)    Images (82)
Theiler Stages: 20, 22, 24, 25, 28
Assay TypeResults
RNA in situ 11
In situ reporter (knock in) 112
RT-PCR 39
cDNA source data(66)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(71) Genomic(1) cDNA(66) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022532 (Evidence)
Ensembl Gene ModelENSMUSG00000035547 (Evidence)
Entrez Gene12337 (Evidence)
UniGene326847
DFCITC1576538
DoTSDT.532227, DT.91368465
NIA Mouse Gene IndexU028880
EC3.4.22.-
Consensus CDS ProjectCCDS21465.1
International Mouse Knockout Project StatusCapn5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022532 VEGA Gene Model | MGI Sequence Detail 56716 C57BL/6J ±  kb
transcript OTTMUST00000053964 VEGA | MGI Sequence Detail 4498 Not Applicable 
polypeptide OTTMUSP00000025702 VEGA | MGI Sequence Detail 640 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(8) UniProt(7)
Polymorphisms SNPs within 2kb(550 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000169 Cysteine peptidase, cysteine active site
InterPro IPR001300 Peptidase C2, calpain, catalytic domain
InterPro IPR022683 Peptidase C2, calpain, domain III
InterPro IPR022684 Peptidase C2, calpain family
InterPro IPR022682 Peptidase C2, calpain, large subunit, domain III
Protein Ontology PR:000005017 calpain-5
References (Earliest) J:43496 Dear N, et al., A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. Genomics. 1997 Oct 1;45(1):175-84
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory