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Wasf2
Gene Detail
 Symbol
Name
ID
Wasf2
WAS protein family, member 2
MGI:1098641
Synonyms D4Ertd13e, WAVE2
Feature Type protein coding gene
Genetic Map
Chromosome 4
66.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:133130505-133199756 bp, + strand
From VEGA annotation of GRCm38

  69252 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86743  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Wiskott-Aldrich syndrome protein
Gene Tree: Wasf2

Human
homologs
Human Homolog WASF2, WAS protein family, member 2
NCBI Gene ID 10163
neXtProt AC  NX_Q9Y6W5
Human Synonyms  dJ393P12.2, IMD2, SCAR2, WASF4, WAVE2
Human Chr (Location)  1p36.11; chr1:27404230-27490167 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(265) : Gene trapped(261) Targeted(4)
Incidental mutations (data from APF )
 
Homozygous mutants show impaired embryonic development and do not survive to term. In addition to reduced embryo size, observed defects include hemorrhaging, abnormal somite development, perturbed angiogenesis, and shrunken cerebral ventricles.
 
Interactions
Wasf2 interacts with 352 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process actin cytoskeleton organization, actin filament-based movement, ...
Component cell-cell junction, cytoplasm, ...
Function actin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (20)    Tissues (19)    Images (9)
Theiler Stages: 10, 15, 18, 23, 25, 28
Assay TypeResults
Immunohistochemistry 6
Western blot 2
RT-PCR 12
cDNA source data(156)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(159) cDNA(156) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000010477 (Evidence)
Ensembl Gene ModelENSMUSG00000028868 (Evidence)
Entrez Gene242687 (Evidence)
UniGene23566
DoTSDT.101385311, DT.110790400, DT.494498, DT.91293659
NIA Mouse Gene IndexU004913
Consensus CDS ProjectCCDS18742.1
International Mouse Knockout Project StatusWasf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010477 VEGA Gene Model | MGI Sequence Detail 69252 C57BL/6J ±  kb
transcript OTTMUST00000024403 VEGA | MGI Sequence Detail 5642 Not Applicable 
polypeptide OTTMUSP00000011229 VEGA | MGI Sequence Detail 497 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(8) UniProt(6)
Polymorphisms SNPs within 2kb(806 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003124 WH2 domain
Protein Ontology PR:000017373 Wiskott-Aldrich syndrome protein family member 2
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:205441 Liang Y, et al., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858-66
All references(60)
Other
accession IDs
MGI:2140610

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory