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Hand1
Gene Detail
 Symbol
Name
ID
Hand1
heart and neural crest derivatives expressed transcript 1
MGI:103577
Synonyms bHLHa27, eHAND, Ehand1, Hxt, Th1, Thing1
Feature Type protein coding gene
Genetic Map
Chromosome 11
35.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:57828707-57832818 bp, - strand
From VEGA annotation of GRCm38

  4112 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:3545  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Hand1
Human
homologs
Human Homolog HAND1, heart and neural crest derivatives expressed 1
NCBI Gene ID 9421
neXtProt AC  NX_O96004
Human Synonyms  bHLHa27, eHand, Hxt, Thing1
Human Chr (Location)  5q33; chr5:153854532-153857824 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(8) : Targeted(8)
 
Homozygotes for targeted null mutations die at embryonic day 8.5-9.5 with yolk sac abnormalities associated with a deficiency of extraembryonic mesoderm and defective trophoblast differentiation. Tetraploid chimeric rescue slightly extends development.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (59 annotations)
Process angiogenesis, cardiac left ventricle formation, ...
Component cytoplasm, nucleolus, ...
Function bHLH transcription factor binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (167 records)
Data Summary: Results (526)    Tissues (322)    Images (108)
Theiler Stages: 2, 3, 4, 5, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 385
Northern blot 44
RT-PCR 91
RNase protection 5
cDNA source data(77)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(102) Genomic(2) cDNA(81) Primer pair(11) Other(8)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000005713 (Evidence)
Ensembl Gene ModelENSMUSG00000037335 (Evidence)
Entrez Gene15110 (Evidence)
UniGene4746
DFCITC1580194
DoTSDT.101238751, DT.482406
NIA Mouse Gene IndexU032799
Consensus CDS ProjectCCDS24721.1
International Mouse Knockout Project StatusHand1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005713 VEGA Gene Model | MGI Sequence Detail 4112 C57BL/6J ±  kb
transcript OTTMUST00000012705 VEGA | MGI Sequence Detail 1904 Not Applicable 
polypeptide OTTMUSP00000005886 VEGA | MGI Sequence Detail 216 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(4)
Polymorphisms RFLP(2) : SNPs(27 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Helix-loop-helix domain
Protein Ontology PR:000008439 heart- and neural crest derivatives-expressed protein 1
References (Earliest) J:22312 Oude Elferink RP, et al., Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse. J Clin Invest. 1995 Jan;95(1):31-8
(Latest) J:195264 Vincentz JW, et al., Twist1 Controls a Cell-Specification Switch Governing Cell Fate Decisions within the Cardiac Neural Crest. PLoS Genet. 2013 Mar;9(3):e1003405
All references(201)
Other
accession IDs 		MGD-MRK-24462, MGD-MRK-25634, MGI:104306
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory