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Rhoa
Gene Detail
Symbol

Name
ID
Rhoa
ras homolog gene family, member A
MGI:1096342
Synonyms
Arha, Arha1, Arha2, RhoA
Feature Type
protein coding gene
Genetic Map
Chromosome 9
59.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:108306129-108337934 bp, + strand
From VEGA annotation of GRCm38

  31806 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68986  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RHOA
Protein SuperFamily: small GTPase, Rho type
Gene Tree: Rhoa

Human
homologs
RHOA, ras homolog family member A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 387
neXtProt AC: NX_P61586

Human Synonyms: ARH12, ARHA, RHO12, RHOH12

Human Chr (Location): 3p21.3; chr3:49359136-49412093 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(228) : Gene trapped(220) Targeted(7) Transgenic(1)
 
Mice homozygous for a conditional allele activated in neuroepithelial cells exhibit lethality during late embryonic stages associated with early cell cycle exit, premature neuronal precursor differentiation, increased apoptosis in the neural tube.
 
Interactions
Rhoa interacts with 249 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (83 annotations)
Process actin cytoskeleton organization, androgen receptor signaling pathway, ...
Component apical junction complex, axon, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (48 records)
Data Summary: Results (111)    Tissues (79)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 71
Western blot 23
cDNA source data(13)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA RHOA ; Xenbase rhoa, rhoa.2 ; ZFIN rhoaa, rhoab, rhoac, rhoad    NEW 
Molecular
reagents
All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000050752 (Evidence)
Ensembl Gene Model ENSMUSG00000007815 (Evidence)
Entrez Gene 11848 (Evidence)
DFCI TC1730528, TC1573100
DoTS DT.102545939, DT.101138346, DT.110611527, DT.99840870, DT.94382596
NIA Mouse Gene Index U145061, U057129, U011020
PDB 4F38
Consensus CDS Project CCDS23521.1
International Mouse Phenotyping Consortium Status Rhoa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050752 VEGA Gene Model | MGI Sequence Detail 31806 C57BL/6J ±  kb
transcript OTTMUST00000128626 VEGA | MGI Sequence Detail 2197 Not Applicable 
polypeptide OTTMUSP00000069171 VEGA | MGI Sequence Detail 193 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(4) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR003578 Small GTPase superfamily, Rho type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000000176 GTP-binding protein RhoA
References
(Earliest) J:87888 Ridley AJ, et al., The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 1992 Aug 7;70(3):389-99
(Latest) J:221822 Boopathi E, et al., Mechanical stretch upregulates proteins involved in Ca2+ sensitization in urinary bladder smooth muscle hypertrophy. Am J Physiol Cell Physiol. 2014 Sep 15;307(6):C542-53
All references(170)
Other
accession IDs
MGI:1355308

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory