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Rhoa
Gene Detail
Symbol

Name
ID
Rhoa
ras homolog gene family, member A
MGI:1096342
Synonyms
Arha, Arha1, Arha2, RhoA
Feature Type
protein coding gene
Genetic Map
Chromosome 9
59.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:108306129-108337934 bp, + strand
From VEGA annotation of GRCm38

  31806 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68986  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: small GTPase, Rho type
Gene Tree: Rhoa

Human
homologs
Human Homolog   RHOA, ras homolog family member A
NCBI Gene ID 387
neXtProt AC  NX_P61586
Human Synonyms  ARH12, ARHA, RHO12, RHOH12
Human Chr (Location)  3p21.3; chr3:49359145-49412093 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(228) : Gene trapped(220) Targeted(7) Transgenic(1)
 
Mice homozygous for a conditional allele activated in neuroepithelial cells exhibit lethality during late embryonic stages associated with early cell cycle exit, premature neuronal precursor differentiation, increased apoptosis in the neural tube.
 
Interactions
Rhoa interacts with 249 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (80 annotations)
Process actin cytoskeleton organization, androgen receptor signaling pathway, ...
Component apical junction complex, axon, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (48 records)
Data Summary: Results (111)    Tissues (79)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 71
Western blot 23
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000050752 (Evidence)
Ensembl Gene ModelENSMUSG00000007815 (Evidence)
Entrez Gene11848 (Evidence)
DFCITC1573100, TC1730528
DoTSDT.101138346, DT.102545939, DT.99840870, DT.94382596, DT.110611527
NIA Mouse Gene IndexU057129, U011020, U145061
PDB4F38
Consensus CDS ProjectCCDS23521.1
International Mouse Knockout Project StatusRhoa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050752 VEGA Gene Model | MGI Sequence Detail 31806 C57BL/6J ±  kb
transcript OTTMUST00000128626 VEGA | MGI Sequence Detail 2197 Not Applicable 
polypeptide OTTMUSP00000069171 VEGA | MGI Sequence Detail 193 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(4) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003578 Small GTPase superfamily, Rho type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000000176 GTP-binding protein RhoA
References
(Earliest) J:87888 Ridley AJ, et al., The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 1992 Aug 7;70(3):389-99
(Latest) J:213772 Liu C, et al., Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a. Biol Open. 2014;3(9):861-70
All references(168)
Other
accession IDs
MGI:1355308

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory