About   Help   FAQ
Rhoa
Gene Detail
 Symbol
Name
ID
Rhoa
ras homolog gene family, member A
MGI:1096342
Synonyms Arha, Arha1, Arha2, RhoA
Feature Type protein coding gene
Genetic Map
Chromosome 9
59.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:108306205-108337939 bp, + strand
From NCBI annotation of GRCm38

  31735 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68986  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: small GTPase, Rho type
Gene Tree: Rhoa

Human
homologs
Human Homolog RHOA, ras homolog family member A
NCBI Gene ID 387
neXtProt AC  NX_P61586
Human Synonyms  ARH12, ARHA, RHO12, RHOH12
Human Chr (Location)  3p21.3; chr3:49359145-49412093 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(225) : Gene trapped(220) Targeted(5)
 
Mice homozygous for a conditional allele activated in neuroepithelial cells exhibit lethality during late embryonic stages associated with early cell cycle exit, premature neuronal precursor differentiation, increased apoptosis in the neural tube.
 
Interactions
Rhoa interacts with 249 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (75 annotations)
Process actin cytoskeleton organization, androgen receptor signaling pathway, ...
Component apical junction complex, axon, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (47 records)
Data Summary: Results (111)    Tissues (79)    Images (36)
Theiler Stages: 4, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 17
RNA in situ 71
Western blot 23
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000007815 (Evidence)
Entrez Gene11848 (Evidence)
DFCITC1573100, TC1730528
DoTSDT.101138346, DT.102545939, DT.110611527, DT.94382596, DT.99840870
NIA Mouse Gene IndexU011020, U057129, U145061
PDB4F38
Consensus CDS ProjectCCDS23521.1
International Mouse Knockout Project StatusRhoa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11848 NCBI Gene Model | MGI Sequence Detail 31735 C57BL/6J ±  kb
transcript NM_016802 RefSeq | MGI Sequence Detail 2126 C57BL/6 
polypeptide Q9QUI0 UniProt | EBI | MGI Sequence Detail 193 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003578 Small GTPase superfamily, Rho type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000000176 GTP-binding protein RhoA
Graphical View of Protein Domain Structure
References (Earliest) J:87888 Ridley AJ, et al., The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 1992 Aug 7;70(3):389-99
(Latest) J:211293 Jennings RT, et al., RhoA determines disease progression by controlling neutrophil motility and restricting hyperresponsiveness. Blood. 2014 Jun 5;123(23):3635-45
All references(163)
Other
accession IDs
MGI:1355308

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory