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Ctsc
Gene Detail
 Symbol
Name
ID
Ctsc
cathepsin C
MGI:109553
Synonyms dipeptidylpeptidase 1, DPP1, DPPI
Feature Type protein coding gene
Genetic Map
Chromosome 7
49.11 cM, cytoband D3-E1.1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:88278085-88310888 bp, + strand
From VEGA annotation of GRCm38

  32804 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:1373  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ctsc
Human
homologs
Human Homolog CTSC, cathepsin C
NCBI Gene ID 1075
neXtProt AC  NX_P53634
Human Synonyms  CPPI, DPP1, DPPI, DPP-I, HMS, JP, JPD, PALS, PDON1, PLS
Human Chr (Location)  11q14.2; chr11:88026760-88070941 (-)  GRCh37.p10
Disease Associations  (3) Diseases Associated with Human CTSC
Alleles
and
phenotypes 		All alleles(3) : Targeted(2) Gene trapped(1)
 
Homozygotes for some targeted null mutations exhibit cytotoxic lymphocytes with inactive granzymes A and B which are incapable of granule-mediated apoptosis. Mutant mast cells lack activated chymase activity. Homozygotes for other alleles display a scruffy coat with age and behavioral abnormalities
 
Human Diseases Modeled Using Mouse Ctsc (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications 		All GO classifications: (14 annotations)
Process proteolysis, response to organic substance, ...
Component endoplasmic reticulum, Golgi apparatus, ...
Function chloride ion binding, cysteine-type peptidase activity, ...
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Results (147)    Tissues (80)    Images (38)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 42
In situ reporter (knock in) 67
RT-PCR 38
cDNA source data(276)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(279) Genomic(2) cDNA(276) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000031137 (Evidence)
Ensembl Gene ModelENSMUSG00000030560 (Evidence)
Entrez Gene13032 (Evidence)
UniGene322945
DFCITC1573181
DoTSDT.103569591, DT.494458
NIA Mouse Gene IndexU008349
EC3.4.14.1
Consensus CDS ProjectCCDS21438.1
International Mouse Knockout Project StatusCtsc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031137 VEGA Gene Model | MGI Sequence Detail 32804 C57BL/6J ±  kb
transcript OTTMUST00000077133 VEGA | MGI Sequence Detail 2493 Not Applicable 
polypeptide OTTMUSP00000040719 VEGA | MGI Sequence Detail 462 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(2) UniProt(11)
Polymorphisms SNPs(243 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR014882 Cathepsin C exclusion
InterPro IPR025661 Cysteine peptidase, asparagine active site
InterPro IPR000169 Cysteine peptidase, cysteine active site
InterPro IPR025660 Cysteine peptidase, histidine active site
InterPro IPR013128 Peptidase C1A, papain
InterPro IPR000668 Peptidase C1A, papain C-terminal
Protein Ontology PR:000006024 dipeptidyl peptidase 1
References (Earliest) J:47503 Paris A, et al., Molecular cloning and sequence analysis of human preprocathepsin C. FEBS Lett. 1995 Aug 7;369(2-3):326-30
(Latest) J:190231 Kono H, et al., The IL-1-dependent sterile inflammatory response has a substantial caspase-1-independent component that requires cathepsin C. J Immunol. 2012 Oct 1;189(7):3734-40
All references(57)
Other
accession IDs 		MGD-MRK-39552, MGI:2141863
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/05/2013
MGI 5.13 		The Jackson Laboratory