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Trpc3 Gene Detail
Summary
  • Symbol
    Trpc3
  • Name
    transient receptor potential cation channel, subfamily C, member 3
  • Synonyms
    Trcp3, Trp3, Trrp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109526
    NCBI Gene: 22065
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:36674626-36744276 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 17.93 cM, cytoband B
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1007 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109526
 protein coding gene Chr3:36674626-36744316 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027163
 protein coding gene Chr3:34431330-34506650 (-)
A/J MGP_AJ_G0027123
 protein coding gene Chr3:33770831-33840102 (-)
AKR/J MGP_AKRJ_G0027092
 protein coding gene Chr3:34387925-34457358 (-)
BALB/cJ MGP_BALBcJ_G0027135
 protein coding gene Chr3:33522557-33596654 (-)
C3H/HeJ MGP_C3HHeJ_G0026878
 protein coding gene Chr3:34452090-34522440 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027581
 protein coding gene Chr3:36075638-36150121 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024942
 protein coding gene Chr3:31462826-31529881 (-)
CAST/EiJ MGP_CASTEiJ_G0026331
 protein coding gene Chr3:34306912-34380245 (-)
CBA/J MGP_CBAJ_G0026855
 protein coding gene Chr3:37057282-37126700 (-)
DBA/2J MGP_DBA2J_G0026989
 protein coding gene Chr3:33221334-33291022 (-)
FVB/NJ MGP_FVBNJ_G0026957
 protein coding gene Chr3:32672681-32742424 (-)
LP/J MGP_LPJ_G0027101
 protein coding gene Chr3:35213618-35286048 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026977
 protein coding gene Chr3:39468751-39546307 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027640
 protein coding gene Chr3:34237259-34312468 (-)
PWK/PhJ MGP_PWKPhJ_G0026064
 protein coding gene Chr3:32868503-32939143 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025876
 protein coding gene Chr3:33611403-33684048 (-)
WSB/EiJ MGP_WSBEiJ_G0026405
 protein coding gene Chr3:34252354-34327812 (-)



Homology
more
  • Human Ortholog
    TRPC3, transient receptor potential cation channel subfamily C member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPC3, transient receptor potential cation channel subfamily C member 3
  • Synonyms
    SCA41, TRP3
  • Links
    NCBI Gene ID: 7222
    neXtProt AC: NX_Q13507
    UniProt: Q13507

  • Chr Location
    4q27; chr4:121874481-121952060 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TRPC3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 5 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    3 images
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout mice or mice heterozygoous for a point mutation in exon 7 display an abnormal gait. Abnormal nervous system electrophysiology is also described. An A1903G point mutation in exon 7 results in homozygous lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    68
  • cDNA Data
    13
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22065 NCBI Gene Model | MGI Sequence Detail 69651 C57BL/6J ±  kb
    transcript NM_019510 RefSeq | MGI Sequence Detail 3659 ZRU/MplStud  
    polypeptide Q9QZC1 UniProt | EBI | MGI Sequence Detail 910 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000000775 short transient receptor potential cation channel TRPC3
      (term hierarchy)
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR005821 Ion transport domain
      IPR013555 Transient receptor ion channel domain
      IPR002153 Transient receptor potential channel, canonical
      IPR005459 Transient receptor potential channel, canonical 3
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 14
      Primer pair 6
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-39525, MGI:3687252
    References
    more
    • Summaries
      All 154
      Developmental Gene Expression 23
      Diseases 1
      Gene Ontology 6
      Phenotypes 83
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:345594 Ming Z, et al., A role for TRPC3 in mammalian testis development. Front Cell Dev Biol. 2024;12:1337714
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory