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Frat1
Gene Detail
 Symbol
Name
ID
Frat1
frequently rearranged in advanced T cell lymphomas
MGI:109450 		BioType Conflict
Feature Type protein coding gene
Genetic Map
Chromosome 19
35.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr19:41830168-41830809 bp, + strand
From Ensembl annotation of GRCm38

  642 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:3999  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Frat1
Human
homologs
Human Homolog FRAT1, frequently rearranged in advanced T-cell lymphomas
NCBI Gene ID 10023
neXtProt AC  NX_Q92837
Human Chr (Location)  10q24.1; chr10:99079022-99081672 (+)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(1) : Targeted(1)
 
Homozygous mice are healthy and fertile with no obvious abnormalities.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (6 annotations)
Process embryonic axis specification, protein export from nucleus
Component cytoplasm, nucleus
Function protein binding
External Resources: FuncBase
Expression Literature Summary: (6 records)
Data Summary: Results (103)    Tissues (83)    Images (12)
Theiler Stages: 12, 16, 19, 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 24
In situ reporter (knock in) 49
Northern blot 16
RT-PCR 14
cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents 		All nucleic(23) Genomic(2) cDNA(17) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000067199 (Evidence)
Entrez Gene14296 (Evidence)
UniGene4573
DFCITC1585150
DoTSDT.490041
NIA Mouse Gene IndexU019456
International Mouse Knockout Project StatusFrat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000067199 Ensembl Gene Model | MGI Sequence Detail 642 C57BL/6J ±  kb
transcript ENSMUST00000087155 Ensembl | MGI Sequence Detail 579 Not Applicable 
polypeptide P70339 UniProt | EBI | MGI Sequence Detail 274 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms PCR(1) : SNPs(7 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR008014 Glycogen synthase kinase-3 binding protein
Protein Ontology PR:000007654 proto-oncogene FRAT1
Graphical View of Protein Domain Structure
References (Earliest) J:38606 Jonkers J, et al., Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas. EMBO J. 1997 Feb 3;16(3):441-50
(Latest) J:183670 Bechard M, et al., Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3beta subcellular localization in pluripotent cells. Mol Cell Biol. 2012 Jan;32(2):288-96
All references(33)
Other
accession IDs 		MGD-MRK-38495, MGI:2147699
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/22/2013
MGI 5.13 		The Jackson Laboratory