About   Help   FAQ
Hmox2 Gene Detail
Summary
  • Symbol
    Hmox2
  • Name
    heme oxygenase 2
  • Synonyms
    HO2, HO-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109373
    NCBI Gene: 15369
  • Gene Overview
    MyGene.info: HMOX2
Location & Maps
more
  • Sequence Map
    Chr16:4726361-4766742 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40382 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 2.46 cM, cytoband B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HMOX2, heme oxygenase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HMOX2, heme oxygenase 2
    Orthology source: HomoloGene
  • Synonyms
    HO-2
  • Links
    NCBI Gene ID: 3163
    neXtProt AC: NX_P30519

  • Chr Location
    16p13.3; chr16:4474703-4510347 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are normal for the most part. However, they are sensitive to incrreases and decreases in oxygen levels and this results in some behavioral and nervous system response abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026637 VEGA Gene Model | MGI Sequence Detail 40382 C57BL/6J ±  kb
transcript OTTMUST00000065914 VEGA | MGI Sequence Detail 1730 Not Applicable  
polypeptide OTTMUSP00000032915 VEGA | MGI Sequence Detail 315 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    94 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 51

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38418
References
more
  • Summaries
    All 75
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 46
  • Earliest
    J:29523 Poss KD, et al., Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron. 1995 Oct;15(4):867-73
  • Latest
    J:224109 Kang L, et al., Induction and functional significance of the heme oxygenase system in pathological shear stress in vivo. Am J Physiol Heart Circ Physiol. 2015 Jun 1;308(11):H1402-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory