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Hmox2 Gene Detail
Summary
  • Symbol
    Hmox2
  • Name
    heme oxygenase 2
  • Synonyms
    HO2, HO-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109373
    NCBI Gene: 15369
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:4544225-4584606 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.46 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    94 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109373
 protein coding gene Chr16:4544225-4584606 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022471
 protein coding gene Chr16:1237913-1273686 (+)
A/J MGP_AJ_G0022433
 protein coding gene Chr16:1052673-1088869 (+)
AKR/J MGP_AKRJ_G0022410
 protein coding gene Chr16:1244755-1278327 (+)
BALB/cJ MGP_BALBcJ_G0022438
 protein coding gene Chr16:1209560-1246432 (+)
C3H/HeJ MGP_C3HHeJ_G0022205
 protein coding gene Chr16:1266655-1302119 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022887
 protein coding gene Chr16:1322355-1360349 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020408
 protein coding gene Chr16:997306-1035139 (+)
CAST/EiJ MGP_CASTEiJ_G0021731
 protein coding gene Chr16:1258160-1297953 (+)
CBA/J MGP_CBAJ_G0022174
 protein coding gene Chr16:1385555-1422750 (+)
DBA/2J MGP_DBA2J_G0022305
 protein coding gene Chr16:1165870-1198329 (+)
FVB/NJ MGP_FVBNJ_G0022280
 protein coding gene Chr16:1151078-1187842 (+)
LP/J MGP_LPJ_G0022373
 protein coding gene Chr16:1233845-1270462 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022302
 protein coding gene Chr16:1247992-1290177 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022899
 protein coding gene Chr16:1209635-1253612 (+)
PWK/PhJ MGP_PWKPhJ_G0021471
 protein coding gene Chr16:1229368-1264890 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021302
 protein coding gene Chr16:1308135-1346111 (+)
WSB/EiJ MGP_WSBEiJ_G0021780
 protein coding gene Chr16:1230102-1264489 (+)



Homology
more
  • Human Ortholog
    HMOX2, heme oxygenase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMOX2, heme oxygenase 2
  • Synonyms
    HO-2
  • Links
    NCBI Gene ID: 3163
    neXtProt AC: NX_P30519
    UniProt: P30519

  • Chr Location
    16p13.3; chr16:4474690-4510347 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are normal for the most part. However, they are sensitive to incrreases and decreases in oxygen levels and this results in some behavioral and nervous system response abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1045
  • Tissues
    137
  • cDNA Data
    50
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15369 NCBI Gene Model | MGI Sequence Detail 40382 C57BL/6J ±  kb
    transcript NM_001378999 RefSeq | MGI Sequence Detail 1868 ZRU/MplStud  
    polypeptide O70252 UniProt | EBI | MGI Sequence Detail 315 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 52
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38418
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 64
    • Earliest
      J:29523 Poss KD, et al., Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron. 1995 Oct;15(4):867-73
    • Latest
      J:343167 Cetin-Atalay R, et al., Loss of heme oxygenase 2 causes reduced expression of genes in cardiac muscle development and contractility and leads to cardiomyopathy in mice. PLoS One. 2023;18(10):e0292990
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory