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Hmox2
Gene Detail
Symbol

Name
ID
Hmox2
heme oxygenase 2
MGI:109373
Synonyms
HO2, HO-2
Feature Type
protein coding gene
Genetic Map
Chromosome 16
2.46 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:4726361-4766742 bp, + strand
From VEGA annotation of GRCm38

  40382 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1611  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: HMOX2
Protein SuperFamily: heme oxygenase (decyclizing)
Gene Tree: Hmox2

Human
homologs
HMOX2, heme oxygenase 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3163
neXtProt AC: NX_P30519

Human Synonyms: HO-2

Human Chr (Location): 16p13.3; chr16:4474703-4510347 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(35) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene are normal for the most part. However, they are sensitive to incrreases and decreases in oxygen levels and this results in some behavioral and nervous system response abnormalities.
 
Interactions
Hmox2 interacts with 91 markers (Mir18, Mir18b, Mir130a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process heme oxidation, oxidation-reduction process, ...
Component endoplasmic reticulum, intracellular membrane-bounded organelle, ...
Function heme oxygenase (decyclizing) activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (211)    Tissues (110)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 197
Northern blot 11
Western blot 3
cDNA source data(49)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hmox2 ; ZFIN hmox2a    NEW 
Molecular
reagents
All nucleic(51) cDNA(51)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026637 (Evidence)
Ensembl Gene Model ENSMUSG00000004070 (Evidence)
Entrez Gene 15369 (Evidence)
DoTS DT.101322105, DT.101152760, DT.101409221, DT.110739541, DT.101409222, DT.110739415, DT.102557618, DT.101409224, DT.99861683, DT.94131451, DT.91409446
EC 1.14.99.3
Consensus CDS Project CCDS27924.1
International Mouse Phenotyping Consortium Status Hmox2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026637 VEGA Gene Model | MGI Sequence Detail 40382 C57BL/6J ±  kb
transcript OTTMUST00000065914 VEGA | MGI Sequence Detail 1730 Not Applicable 
polypeptide OTTMUSP00000032915 VEGA | MGI Sequence Detail 315 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(8) UniProt(6)
Polymorphisms
SNPs within 2kb(94 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002051 Haem oxygenase
InterPro IPR018207 Haem oxygenase conserved site
InterPro IPR016053 Haem oxygenase-like
InterPro IPR016084 Haem oxygenase-like, multi-helical
Protein Ontology PR:000008645 heme oxygenase 2
References
(Earliest) J:29523 Poss KD, et al., Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron. 1995 Oct;15(4):867-73
(Latest) J:218017 Bellner L, et al., Heme oxygenase-2 deletion impairs macrophage function: implication in wound healing. FASEB J. 2015 Jan;29(1):105-15
All references(73)
Other
accession IDs
MGD-MRK-38418

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory