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Htr2b
Gene Detail
 Symbol
Name
ID
Htr2b
5-hydroxytryptamine (serotonin) receptor 2B
MGI:109323
Synonyms 5-HT2B
Feature Type protein coding gene
Genetic Map
Chromosome 1
43.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:86099026-86111970 bp, - strand
From VEGA annotation of GRCm38

  12945 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology 		HomoloGene:55492  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: 5-hydroxytryptamine receptor 2
Gene Tree: Htr2b
Human
homologs
Human Homolog HTR2B, 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
NCBI Gene ID 3357
neXtProt AC  NX_P41595
Human Synonyms  5-HT2B, 5-HT(2B)
Human Chr (Location)  2q36.3-q37.1; chr2:231972947-231989824 (-)  GRCh37.p10
Alleles
and
phenotypes 		All alleles(6) : Targeted(6)
 
Homozygotes for a targeted null mutation exhibit a lack of cardiac trabeculae, ventricular hypoplasia due to impaired myocyte proliferation, and midgestational and neonatal lethality of variable severity.
 
Gene Ontology
(GO)
classifications 		All GO classifications: (72 annotations)
Process behavior, calcium ion transmembrane transport, ...
Component cytoplasm, integral to membrane, ...
Function calcium channel activity, drug binding, ...
External Resources: FuncBase
Expression Literature Summary: (10 records)
Data Summary: Results (204)    Tissues (113)    Images (24)
Theiler Stages: 12, 13, 14, 15, 16, 17, 19, 21, 23, 28
Assay TypeResults
Immunohistochemistry 11
RNA in situ 49
In situ reporter (knock in) 47
RT-PCR 97
cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents 		All nucleic(13) Genomic(2) cDNA(6) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033955 (Evidence)
Ensembl Gene ModelENSMUSG00000026228 (Evidence)
Entrez Gene15559 (Evidence)
UniGene439747
DFCITC1587726
DoTSDT.101723987, DT.101723988, DT.99845142
NIA Mouse Gene IndexU021555
Consensus CDS ProjectCCDS35644.1
International Mouse Knockout Project StatusHtr2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033955 VEGA Gene Model | MGI Sequence Detail 12945 C57BL/6J ±  kb
transcript OTTMUST00000085661 VEGA | MGI Sequence Detail 2083 Not Applicable 
polypeptide OTTMUSP00000046300 VEGA | MGI Sequence Detail 479 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(3)
Polymorphisms SNPs(86 from dbSNP Build 128)
Protein-related
information
ResourceIDDescription
InterPro IPR000482 5-Hydroxytryptamine 2B receptor
InterPro IPR002231 5-Hydroxytryptamine receptor
InterPro IPR000276 GPCR, rhodopsin-like
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
Protein Ontology PR:000001167 5-hydroxytryptamine receptor 2B
References (Earliest) J:3106 Loric S, et al., New mouse 5-HT2-like receptor. Expression in brain, heart and intestine. FEBS Lett. 1992 Nov 9;312(2-3):203-7
(Latest) J:190895 Sumara G, et al., Gut-derived serotonin is a multifunctional determinant to fasting adaptation. Cell Metab. 2012 Nov 7;16(5):588-600
All references(73)
Other
accession IDs 		MGD-MRK-38368, MGI:2138380, MGI:2138536
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory